User profiles for H. Wulff

Heike Wulff

Profesor of Pharmacology, University of California, Davis
Verified email at ucdavis.edu
Cited by 19846

Voltage-gated potassium channels as therapeutic targets

H Wulff, NA Castle, LA Pardo - Nature reviews Drug discovery, 2009 - nature.com
The human genome encodes 40 voltage-gated K + channels (K V ), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Ion channels in innate and adaptive immunity

S Feske, H Wulff, EY Skolnik - Annual review of immunology, 2015 - annualreviews.org
… The primary function of H + extrusion via H V 1 is to balance the intracellular pH following
an acid load (107, 113) and to repolarize the PM potential following the outward electron flux …

K+ channels as targets for specific immunomodulation

KG Chandy, H Wulff, C Beeton, M Pennington… - Trends in …, 2004 - cell.com
The voltage-gated Kv1.3 channel and the Ca 2+ -activated IKCa1 K + channel are expressed
in T cells in a distinct pattern that depends on the state of lymphocyte activation and …

Kv1. 3 channels are a therapeutic target for T cell-mediated autoimmune diseases

C Beeton, H Wulff, NE Standifer… - Proceedings of the …, 2006 - National Acad Sciences
Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune
diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with …

Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant

H Wulff, MJ Miller, W Hänsel… - Proceedings of the …, 2000 - National Acad Sciences
… Triated thymidine ([ 3 H]TdR) (1 μCi per well) was added for the last 6 h. Cells were
harvested onto glass fiber filters and radioactivity measured in a scintillation counter. …

The concise guide to pharmacology 2021/22: Ion channels

…, AD Wei, BT Winn, H Wulff, H Xu… - British Journal of …, 2021 - Wiley Online Library
… in table), heterologous expression of ASIC2b alone does not support H+-gated currents.
A third member, ASIC3 (DRASIC, TNaC1) [1108] is one of the most pH-sensitive isoforms (along …

[HTML][HTML] Up-regulation of the IKCa1 potassium channel during T-cell activation: molecular mechanism and functional consequences

S Ghanshani, H Wulff, MJ Miller, H Rohm… - Journal of Biological …, 2000 - ASBMB
We used whole cell recording to evaluate functional expression of the intermediate conductance
Ca 2+ -activated K + channel,IKCa1, in response to various mitogenic stimuli. One to …

[HTML][HTML] The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

H Wulff, PA Calabresi, R Allie, S Yun… - The Journal of …, 2003 - Am Soc Clin Investig
… One aliquot was pulsed with [ 3 H]TdR for the last 12 hours and [ 3 H]TdR incorporation was
… During the last 12 hours it was pulsed with [ 3 H]TdR, and then [ 3 H]TdR incorporation was …

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

…, MM Tamkun, CA Vandenberg, A Wei, H Wulff… - Pharmacological …, 2003 - ASPET
This summary article presents an overview of the molecular relationships among the voltage-gated
potassium channels and a standard nomenclature for them, which is derived from the …

[BOOK][B] Youth cultures: A cross-cultural perspective

V Amit, H Wulff - 2022 - books.google.com
… rather than active role of youth, reinforced through the discourse of resistance, is beginning
to receive some scholarly attention and critique (see Amit-Talai, chapters 7 and 10 and Wulff, …