L-DOPA treatment selectively restores spine density in dopamine receptor D2–expressing projection neurons in dyskinetic mice
Background L-3,4-dihydroxyphenylalanine (L-DOPA)–induced dyskinesia is an incapacitating
complication of L-DOPA therapy that affects most patients with Parkinson’s disease. …
complication of L-DOPA therapy that affects most patients with Parkinson’s disease. …
The Kinase Fyn As a Novel Intermediate in l-DOPA-Induced Dyskinesia in Parkinson's Disease
…, G Gomez, MA Bernardi, L Isaja, IR Taravini… - Molecular …, 2018 - Springer
Dopamine replacement therapy with l-DOPA is the treatment of choice for Parkinson’s disease;
however, its long-term use is frequently associated with l-DOPA-induced dyskinesia (LID)…
however, its long-term use is frequently associated with l-DOPA-induced dyskinesia (LID)…
Contrasting gene expression patterns induced by levodopa and pramipexole treatments in the rat model of Parkinson's disease
IR Taravini, C Larramendy, G Gomez, MD Saborido… - …, 2016 - Elsevier
… , the presence of TH-immunoreactive (TH-ir) cells was evaluated on the lesioned and non-lesioned
hemisphere. The proportion of TH-ir cells remaining in the SNpc injected with 6-…
hemisphere. The proportion of TH-ir cells remaining in the SNpc injected with 6-…
Regulation of Pleiotrophin and Fyn in the striatum of rats undergoing l-DOPA-induced dyskinesia
…, MA Bernardi, OS Gershanik, IR Taravini… - Neuroscience …, 2018 - Elsevier
L-DOPA is the gold standard pharmacological therapy for symptomatic treatment of
Parkinson's disease (PD), however, its long-term use is associated with the emergence of L-DOPA-…
Parkinson's disease (PD), however, its long-term use is associated with the emergence of L-DOPA-…
[PDF][PDF] Decrease of a current mediated by Kv1. 3 channels causes striatal cholinergic interneuron hyperexcitability in experimental parkinsonism
C Tubert, IRE Taravini, E Flores-Barrera, GM Sanchez… - Cell reports, 2016 - cell.com
The mechanism underlying a hypercholinergic state in Parkinson's disease (PD) remains
uncertain. Here, we show that disruption of the K v 1 channel-mediated function causes …
uncertain. Here, we show that disruption of the K v 1 channel-mediated function causes …
Changes in Dendritic Spine Density and Inhibitory Perisomatic Connectivity onto Medium Spiny Neurons in l-Dopa-Induced Dyskinesia
…, MG Murer, OS Gershanik, IRE Taravini - Molecular …, 2019 - Springer
… Furthermore, we expected that if the decrease in PV-ir boutons and cell density were due
to a decrease in PV expression but not a decrease in FSI number, then there should be an …
to a decrease in PV expression but not a decrease in FSI number, then there should be an …
[HTML][HTML] Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats
IRE Taravini, M Chertoff, EG Cafferata, J Courty… - Molecular …, 2011 - Springer
… (A) Values (mean ± SEM) are the percentage of TH-immunoreactive (TH-ir) neurons
remaining in the substantia nigra injected with AdPTN or Adβgal compared to the contralateral …
remaining in the substantia nigra injected with AdPTN or Adβgal compared to the contralateral …
Loss of homeostasis in the direct pathway in a mouse model of asymptomatic Parkinson's disease
MV Escande, IRE Taravini, CL Zold… - Journal of …, 2016 - Soc Neuroscience
The characteristic slowness of movement in Parkinson9s disease relates to an imbalance in
the activity of striatal medium spiny neurons (MSNs) of the direct (dMSNs) and indirect (…
the activity of striatal medium spiny neurons (MSNs) of the direct (dMSNs) and indirect (…
[HTML][HTML] Altered corticostriatal connectivity and exploration/exploitation imbalance emerge as intermediate phenotypes for a neonatal dopamine dysfunction
BY Braz, GL Galiñanes, IRE Taravini… - …, 2015 - nature.com
Findings showing that neonatal lesions of the forebrain dopaminergic system in rodents lead
to juvenile locomotor hyperactivity and learning deficits have been taken as evidence of …
to juvenile locomotor hyperactivity and learning deficits have been taken as evidence of …
Immunodetection of heparin-binding growth associated molecule (pleiotrophin) in striatal interneurons
IRE Taravini, JE Ferrario, J Delbe, L Ginestet, T Debeir… - Brain research, 2005 - Elsevier
Pleiotrophin (PTN), a developmentally-regulated trophic factor, is over-expressed in the
striatum of parkinsonian rats. Because striatal PTN can provide trophic support to dopamine …
striatum of parkinsonian rats. Because striatal PTN can provide trophic support to dopamine …