[HTML][HTML] Anti-virulence strategies to combat bacteria-mediated disease

DA Rasko, V Sperandio - Nature reviews Drug discovery, 2010 - nature.com
Antibiotic resistance is one of the greatest challenges of the twenty-first century. However,
the increasing understanding of bacterial pathogenesis and intercellular communication has …

Interactions between the microbiota and pathogenic bacteria in the gut

AJ Bäumler, V Sperandio - Nature, 2016 - nature.com
The microbiome has an important role in human health. Changes in the microbiota can
confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound …

Inter-kingdom signalling: communication between bacteria and their hosts

DT Hughes, V Sperandio - Nature Reviews Microbiology, 2008 - nature.com
Microorganisms and their hosts communicate with each other through an array of hormonal
signals. This cross-kingdom cell-to-cell signalling involves small molecules, such as …

An alternative, nonapoptotic form of programmed cell death

S Sperandio, I de Belle… - Proceedings of the …, 2000 - National Acad Sciences
The term apoptosis often has been used interchangeably with the term programmed cell
death. Here we describe a form of programmed cell death that is distinct from apoptosis by the …

[HTML][HTML] A unified model for apical caspase activation

KM Boatright, M Renatus, FL Scott, S Sperandio… - Molecular cell, 2003 - cell.com
Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two-step
proteolytic cascade. Existing data suggests that apical caspases are activated by adaptor-…

Bacteria–host communication: the language of hormones

V Sperandio, AG Torres, B Jarvis… - Proceedings of the …, 2003 - National Acad Sciences
The interbacterial communication system known as quorum sensing (QS) utilizes hormone-like
compounds referred to as autoinducers to regulate bacterial gene expression. …

The Pangenome Structure of Escherichia coli: Comparative Genomic Analysis of E. coli Commensal and Pathogenic Isolates

…, R Chaudhuri, IR Henderson, V Sperandio… - Journal of …, 2008 - Am Soc Microbiol
Whole-genome sequencing has been skewed toward bacterial pathogens as a consequence
of the prioritization of medical and veterinary diseases. However, it is becoming clear that …

[HTML][HTML] Gut microbiota and short chain fatty acids: implications in glucose homeostasis

…, E Lanza, M Khalil, DQH Wang, M Sperandio… - International journal of …, 2022 - mdpi.com
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the …

Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two‐component regulatory system involved in the regulation of flagella and motility by quorum sensing in …

V Sperandio, AG Torres, JB Kaper - Molecular microbiology, 2002 - Wiley Online Library
Quorum sensing is a cell‐to‐cell signalling mechanism in which bacteria secrete hormone‐like
compounds called autoinducers. When these auto‐inducers reach a certain threshold …

The QseC sensor kinase: a bacterial adrenergic receptor

…, C Zhu, EC Boedeker, V Sperandio - Proceedings of the …, 2006 - National Acad Sciences
Quorum sensing is a cell-to-cell signaling mechanism in which bacteria respond to hormone-like
molecules called autoinducers (AIs). The AI-3 quorum-sensing system is also involved …