Plasticity at excitatory glutamatergic synapses in the central nervous system is believed to be
critical for neuronal circuits to process and encode information, allowing animals to perform …

Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca 2+ /calmodulin
(CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-…

Information processing in the brain requires multiple forms of synaptic plasticity that converge
on regulation of NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR), including …

L-type voltage-gated Ca 2+ channels (LTCC) couple neuronal excitation to gene transcription.
LTCC activity is elevated by the cyclic AMP (cAMP)-dependent protein kinase (PKA) and …

AMPA receptors (AMPARs) are tetrameric ion channels assembled from GluA1–GluA4
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …

NMDA receptor-dependent long-term potentiation (LTP) and depression (LTD) are forms of
synaptic plasticity underlying learning and memory that are expressed through increases …

Phosphorylation and dephosphorylation of AMPA-type ionotropic glutamate receptors (AMPARs)
by kinases and phosphatases and interactions with scaffold proteins play essential …

This important study reports selective CDKL5 inhibitors that may be of high interest to
investigate the role of this kinase in disease (particularly, in CDKL5 deficiency disorder) and to …

Early‐life ecological conditions have major effects on survival and reproduction. Numerous
studies in wild systems show fitness benefits of good quality early‐life ecological conditions (“…

Neuronal information processing requires multiple forms of synaptic plasticity mediated by
NMDARs and AMPA-type glutamate receptors (AMPARs). These plasticity mechanisms …