User profiles for J. M. Dell'Orco

James M. Dell'Orco

Reserach Associate, University of Michigan
Verified email at umich.edu
Cited by 813

Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3

…, M do Carmo Costa, JM Dell'Orco… - Journal of …, 2011 - Soc Neuroscience
The relationship between cerebellar dysfunction, motor symptoms, and neuronal loss in the
inherited ataxias, including the polyglutamine disease spinocerebellar ataxia type 3 (SCA3), …

Neuronal atrophy early in degenerative ataxia is a compensatory mechanism to regulate membrane excitability

JM Dell'Orco, AH Wasserman, R Chopra… - Journal of …, 2015 - Soc Neuroscience
Neuronal atrophy in neurodegenerative diseases is commonly viewed as an early event in
a continuum that ultimately results in neuronal loss. In a mouse model of the polyglutamine …

Potassium channel dysfunction underlies Purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2

JM Dell'Orco, SM Pulst… - Human molecular …, 2017 - academic.oup.com
Alterations in Purkinje neuron firing often accompany ataxia, but the molecular basis for
these changes is poorly understood. In a mouse model of spinocerebellar ataxia type 2 (SCA2), …

[HTML][HTML] The influence of subthalamic nucleus lesions on sign-tracking to stimuli paired with food and drug rewards: facilitation of incentive salience attribution?

JM Uslaner, JM Dell'Orco, A Pevzner… - …, 2008 - nature.com
It is well known that the subthalamic nucleus (STN) plays an important role in regulating
motor function, but recent studies suggest the STN is also involved in regulating motivated …

[HTML][HTML] Heat shock protein beta-1 modifies anterior to posterior Purkinje cell vulnerability in a mouse model of Niemann-Pick type C disease

C Chung, MJ Elrick, JM Dell'Orco, ZS Qin… - PLoS …, 2016 - journals.plos.org
Selective neuronal vulnerability is characteristic of most degenerative disorders of the CNS,
yet mechanisms underlying this phenomenon remain poorly characterized. Many forms of …

Progress and challenges of the ITER TBM Program from the IO perspective

…, G Dell'Orco, J Elbez-Uzan, JM Fourneron… - Fusion Engineering and …, 2016 - Elsevier
The paper describes the organization of the Test Blanket Module (TBM) program, its overall
objective and schedule and the status of the technical activities within the ITER Organization-…

Key green engineering research areas for sustainable manufacturing: a perspective from pharmaceutical and fine chemicals manufacturers

…, C Bertsch, RE Hannah, P Dell'Orco… - … Process Research & …, 2011 - ACS Publications
In 2005, the American Chemical Society (ACS) Green Chemistry Institute (GCI) and global
pharmaceutical companies established the ACS GCI Pharmaceutical Roundtable to …

Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells

…, JR Smith, EL Schneider, R Dell'Orco… - … and cellular biology, 1991 - Am Soc Microbiol
Genes that act inside the cell to negatively regulate proliferation are of great interest because
of their implications for such processes as development and cancer, but these genes have …

Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver

…, EL Schneider, CK Lumpkin, RT Dell'Orco… - Biochemical and …, 1989 - Elsevier
Studies of chromosome loss in inherited cancers, of fusions between proliferating and
quiescent cells, and of microinjection of RNA from quiescent cells into proliferation competent …

[PDF][PDF] A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning

…, SK Amoah, R Lin, E Lozano, C Pierotti, M Dell'Orco… - Cell reports, 2022 - cell.com
Although circular RNAs (circRNAs) are enriched in the brain, their relevance for brain
function and psychiatric disorders is poorly understood. Here, we show that circHomer1 is …