The hippocampus is traditionally thought to transmit contextual information to limbic structures
where it acquires valence. Using freely moving calcium imaging and optogenetics, we …

Animals associate cues with outcomes and update these associations as new information is
presented. This requires the hippocampus, yet how hippocampal neurons track changes in …

Despite the known adverse consequences of prenatal alcohol exposure, some pregnant
women continue to drink alcohol, making it imperative to identify treatments for children with …

Animals must discern important stimuli and place them onto their cognitive map of their
environment. The neocortex conveys general representations of sensory events to the …

We used viral intersectional tools to map the entire projectome of corticospinal neurons
associated with fine distal forelimb control in Fischer 344 rats and rhesus macaques. In rats, we …

Layer 5 neurons of the neocortex receive direct and relatively strong input from the thalamus.
However, the intralaminar distribution of these inputs and their capacity for plasticity in …

Recurrent synaptic connections between neighboring neurons are a key feature of mammalian
cortex, accounting for the vast majority of cortical inputs. Although computational models …

Behavior is derived from the configuration of synaptic connectivity among functionally diverse
neurons. Fine motor behavior is absent at birth in most mammals but gradually emerges …

Layer 5 neurons of the neocortex receive their principal inputs from layer 2/3 neurons. We
seek to identify the nature and extent of the plasticity of these projections with motor learning. …

Fifty years ago it was discovered that the dentate gyrus (DG) subfield of the hippocampus is
one of the few areas of the brain where new neurons are generated throughout adulthood (…