User profiles for J. S. Pachter

Joel Pachter

UConn Health
Verified email at uchc.edu
Cited by 11276

The blood-brain barrier and its role in immune privilege in the central nervous system

JS Pachter, HE de Vries, Z Fabry - Journal of Neuropathology & …, 2003 - academic.oup.com
The blood-brain barrier (BBB) provides both anatomical and physiological protection for the
central nervous system (CNS), strictly regulating the entry of many substances and blood …

Where is the blood–brain barrier… really?

S Ge, L Song, JS Pachter - Journal of neuroscience research, 2005 - Wiley Online Library
Few terms in the biomedical lexicon are as widely recognized as the phrase blood–brain
barrier (BBB). Indeed, it immediately conjures up a “barricade” between the blood and the brain…

[HTML][HTML] Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

…, AM Andrews, D Paul, JS Pachter - Fluids and Barriers of the …, 2018 - Springer
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the
blood and other body fluids, which disperse a variety of bioactive molecules (eg, protein, …

[HTML][HTML] Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia

…, SM O'Mara, Z Najda, SG Campbell, JS Pachter… - Molecular …, 2018 - nature.com
Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general
population. Various genes show associations with schizophrenia and a very weak nominal …

Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells

L Song, S Ge, JS Pachter - Blood, 2007 - ashpublications.org
… Song L and Pachter JS. Culture of murine brain microvascular endothelial cells that
maintain expression and cytoskeletal association of tight junction-associated proteins. …

[HTML][HTML] Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis

…, J Chu, NA Kouris, GJ Yavanian, SJ Lu, JS Pachter… - Stem cell reports, 2014 - cell.com
Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal
stem cells (MSCs) harbor regenerative and immunosuppressive functions, indicating a …

Monocyte chemoattractant protein-1 alters expression of tight junction-associated proteins in brain microvascular endothelial cells

L Song, JS Pachter - Microvascular research, 2004 - Elsevier
… Author links open overlay panel Li Song , Joel S Pachter … /v] Triton X-100) that highlights
the cytoskeletal framework (CSK; Pachter, 1992) and the TJ-associated proteins adherent to this …

Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study

AV Andjelkovic, B Nikolic, JS Pachter, N Zecevic - Brain research, 1998 - Elsevier
The development of microglia and macrophages was studied in 14 human embryos and
fetuses ranging in age from 4.5–13.5 gestational weeks (gw), using lectins, Ricinus communis …

Isolation and culture of microvascular endothelial cells from murine spinal cord

S Ge, JS Pachter - Journal of neuroimmunology, 2006 - Elsevier
… 1, all commonly exemplified in BMEC cultures proposed as BBB models (Song and Pachter,
2004), are likewise manifest in cultured SCMEC. … Song and Pachter, 2004 … Song, JS Pachter

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

JS Pachter, TJ Yen, DW Cleveland - Cell, 1987 - cell.com
We have utilized protein synthesis inhlbltors to investigate the autoregulatory mechanism that
uses the concentration of unpolymerized tubulln subunits to specify tubulin mRNA content …