[HTML][HTML] Sources of type I interferons in infectious immunity: plasmacytoid dendritic cells not always in the driver's seat
…, A Schulze, L Richter, J Alferink… - Frontiers in …, 2019 - frontiersin.org
Type I Interferons (IFNs) are hallmark cytokines produced in immune responses to all classes
of pathogens. Type I IFNs can influence dendritic cell (DC) activation, maturation, migration…
of pathogens. Type I IFNs can influence dendritic cell (DC) activation, maturation, migration…
[HTML][HTML] The CC chemokines CCL17 and CCL22 and their receptor CCR4 in CNS autoimmunity
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous
system (CNS). It affects more than two million people worldwide, mainly young adults, and …
system (CNS). It affects more than two million people worldwide, mainly young adults, and …
[HTML][HTML] Mitochondria, microglia, and the immune system—how are they linked in affective disorders?
Major depressive disorder (MDD) is a severe mood disorder and frequently associated with
alterations of the immune system characterized by enhanced levels of circulating pro-…
alterations of the immune system characterized by enhanced levels of circulating pro-…
T cell awareness of paternal alloantigens during pregnancy
A Tafuri, J Alferink, P Möller, GJ Hämmerling, B Arnold - Science, 1995 - science.org
During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells
specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell …
specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell …
The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity
…, K Saijo, J Flossdorf, S Hucke, J Alferink… - Journal of Experimental …, 2009 - rupress.org
T helper cells secreting interleukin (IL)-17 (Th17 cells) play a crucial role in autoimmune
diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by a combination of …
diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by a combination of …
Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer's disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial
…, JP Bach, J Popp, J Alferink, J Wiltfang… - The Lancet …, 2013 - thelancet.com
Background Three small trials suggest that intravenous immunoglobulin can affect biomarkers
and symptoms of mild-to-moderate Alzheimer's disease. We tested the safety, effective …
and symptoms of mild-to-moderate Alzheimer's disease. We tested the safety, effective …
Crucial role of CB2 cannabinoid receptor in the regulation of central immune responses during neuropathic pain
…, X Nadal, J Alferink, JE Banos, J Rehnelt… - Journal of …, 2008 - Soc Neuroscience
Neuropathic pain is a clinical manifestation of nerve injury difficult to treat even with potent
analgesic compounds. Here, we used different lines of genetically modified mice to clarify the …
analgesic compounds. Here, we used different lines of genetically modified mice to clarify the …
Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin β in mesenteric lymph node genesis
The recently described tumor necrosis factor (TNF) family member LIGHT (herpes virus
entry mediator [HVEM]-L/TNFSF14), a ligand for the lymphotoxin (LT)β receptor, HVEM, and …
entry mediator [HVEM]-L/TNFSF14), a ligand for the lymphotoxin (LT)β receptor, HVEM, and …
Prediction of individual response to electroconvulsive therapy via machine learning on structural magnetic resonance imaging data
…, P Wahl, W Heindel, V Arolt, J Alferink… - JAMA …, 2016 - jamanetwork.com
Importance Electroconvulsive therapy (ECT) is one of the most effective treatments for
severe depression. However, biomarkers that accurately predict a response to ECT remain …
severe depression. However, biomarkers that accurately predict a response to ECT remain …
Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen
J Alferink, I Lieberam, W Reindl, A Behrens… - The Journal of …, 2003 - rupress.org
Dendritic cells (DCs) * * Abbreviations used in this paper: BM, bone marrow; CHS, contact
hypersensitivity; cLN, cutaneous lymph node; CRP, C-reactive protein; DC, dendritic cell; …
hypersensitivity; cLN, cutaneous lymph node; CRP, C-reactive protein; DC, dendritic cell; …