User profiles for J. Brugge

JOAN BRUGGE

Harvard Medical School
Verified email at hms.harvard.edu
Cited by 66109

Integrins and signal transduction pathways: the road taken

EA Clark, JS Brugge - Science, 1995 - science.org
Adhesive interactions play critical roles in directing the migration, proliferation, and
differentiation of cells; aberrations in such interactions can lead to pathological disorders. These …

Cellular functions regulated by Src family kinases

SM Thomas, JS Brugge - Annual review of cell and …, 1997 - annualreviews.org
J Brugge, unpublished results). Since mutational studies suggest that phosphorylation of
Y416 plays a role in regulation of its catalytic activity, phosphorylation of this tyrosine could be …

Modelling glandular epithelial cancers in three-dimensional cultures

J Debnath, JS Brugge - Nature Reviews Cancer, 2005 - nature.com
… ; i is stained for P-ERM, a protein located at the juxtamembrane cytoskeleton that therefore
marks cell borders, which was used to illustrate the size and shape of cells in this structure; j

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

…, S Thomas, J Brugge, PG Pelicci, J Schlessinger… - Nature, 1992 - nature.com
THE mammalian shc gene encodes two overlapping, widely expressed proteins of 46 and
52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a …

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

J Debnath, SK Muthuswamy, JS Brugge - Methods, 2003 - Elsevier
… Mina Bissell (Lawrence Berkeley Laboratories), as well as members of the Brugge and
Bissell laboratories, for assistance in developing and optimizing the protocols presented in this …

[HTML][HTML] A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

…, J Michaelson, A Bhan, K Habin, TM Baer, J Brugge… - Cancer cell, 2004 - cell.com
Tamoxifen significantly reduces tumor recurrence in certain patients with early-stage estrogen
receptor-positive breast cancer, but markers predictive of treatment failure have not been …

Phase-locked response to low-frequency tones in single auditory nerve fibers of the squirrel monkey.

JE Rose, JF Brugge, DJ Anderson… - Journal of …, 1967 - journals.physiology.org
RESULTS Our findings concerning the response areas of the individual units are in agreement
with observations of Kiang and co-workers (9) and to a large extent with those of other …

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

…, L Chin, G Wagner, JM Asara, JS Brugge… - Nature …, 2011 - nature.com
Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which
glucose-derived metabolic fluxes are used for alternative processes is poorly understood 1 , 2 …

Engineering tumors with 3D scaffolds

…, R Chen, T Matsumoto, T Schmelzle, JS Brugge… - Nature …, 2007 - nature.com
Microenvironmental conditions control tumorigenesis and biomimetic culture systems that
allow for in vitro and in vivo tumor modeling may greatly aid studies of cancer cells' …

[HTML][HTML] Mutant p53 drives invasion by promoting integrin recycling

…, RL Ludwig, P Gosselin, A Cromer, JS Brugge… - Cell, 2009 - cell.com
p53 is a tumor suppressor protein whose function is frequently lost in cancers through
missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 …