User profiles for J. Brugge
JOAN BRUGGEHarvard Medical School Verified email at hms.harvard.edu Cited by 66109 |
Integrins and signal transduction pathways: the road taken
EA Clark, JS Brugge - Science, 1995 - science.org
Adhesive interactions play critical roles in directing the migration, proliferation, and
differentiation of cells; aberrations in such interactions can lead to pathological disorders. These …
differentiation of cells; aberrations in such interactions can lead to pathological disorders. These …
Cellular functions regulated by Src family kinases
SM Thomas, JS Brugge - Annual review of cell and …, 1997 - annualreviews.org
… J Brugge, unpublished results). Since mutational studies suggest that phosphorylation of
Y416 plays a role in regulation of its catalytic activity, phosphorylation of this tyrosine could be …
Y416 plays a role in regulation of its catalytic activity, phosphorylation of this tyrosine could be …
Modelling glandular epithelial cancers in three-dimensional cultures
… ; i is stained for P-ERM, a protein located at the juxtamembrane cytoskeleton that therefore
marks cell borders, which was used to illustrate the size and shape of cells in this structure; j …
marks cell borders, which was used to illustrate the size and shape of cells in this structure; j …
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
…, S Thomas, J Brugge, PG Pelicci, J Schlessinger… - Nature, 1992 - nature.com
THE mammalian shc gene encodes two overlapping, widely expressed proteins of 46 and
52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a …
52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a …
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
… Mina Bissell (Lawrence Berkeley Laboratories), as well as members of the Brugge and
Bissell laboratories, for assistance in developing and optimizing the protocols presented in this …
Bissell laboratories, for assistance in developing and optimizing the protocols presented in this …
[HTML][HTML] A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
Tamoxifen significantly reduces tumor recurrence in certain patients with early-stage estrogen
receptor-positive breast cancer, but markers predictive of treatment failure have not been …
receptor-positive breast cancer, but markers predictive of treatment failure have not been …
Phase-locked response to low-frequency tones in single auditory nerve fibers of the squirrel monkey.
JE Rose, JF Brugge, DJ Anderson… - Journal of …, 1967 - journals.physiology.org
RESULTS Our findings concerning the response areas of the individual units are in agreement
with observations of Kiang and co-workers (9) and to a large extent with those of other …
with observations of Kiang and co-workers (9) and to a large extent with those of other …
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which
glucose-derived metabolic fluxes are used for alternative processes is poorly understood 1 , 2 …
glucose-derived metabolic fluxes are used for alternative processes is poorly understood 1 , 2 …
Engineering tumors with 3D scaffolds
Microenvironmental conditions control tumorigenesis and biomimetic culture systems that
allow for in vitro and in vivo tumor modeling may greatly aid studies of cancer cells' …
allow for in vitro and in vivo tumor modeling may greatly aid studies of cancer cells' …
[HTML][HTML] Mutant p53 drives invasion by promoting integrin recycling
…, RL Ludwig, P Gosselin, A Cromer, JS Brugge… - Cell, 2009 - cell.com
p53 is a tumor suppressor protein whose function is frequently lost in cancers through
missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 …
missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 …