User profiles for J. Climer
 | Jason ClimerPostdoctoral Fellow, Northwestern University Verified email at northwestern.edu Cited by 905 |
[HTML][HTML] Cholinergic modulation of cognitive processing: insights drawn from computational models
Acetylcholine plays an important role in cognitive function, as shown by pharmacological
manipulations that impact working memory, attention, episodic memory and spatial memory …
manipulations that impact working memory, attention, episodic memory and spatial memory …
[PDF][PDF] Multiple running speed signals in medial entorhinal cortex
… (J) There is no relationship between the firing rate pseudo-r2 values and the oscillatory
frequency pseudo-r2 values. … J) Same as in I, but for cells identified as saturating. …
frequency pseudo-r2 values. … J) Same as in I, but for cells identified as saturating. …
Cholinergic blockade reduces theta-gamma phase amplitude coupling and speed modulation of theta frequency consistent with behavioral effects on encoding
Large-scale neural activation dynamics in the hippocampal-entorhinal circuit local field
potential, observable as theta and gamma rhythms and coupling between these rhythms, is …
potential, observable as theta and gamma rhythms and coupling between these rhythms, is …
Phase coding by grid cells in unconstrained environments: two‐dimensional phase precession
… where θ j denotes the theta phase of the jth spike, urn:x-wiley:0953816X:media:ejn12256:ejn12256-math-0021
is derived from the pass index at the time of the spike P j , and urn:x-wiley…
is derived from the pass index at the time of the spike P j , and urn:x-wiley…
[HTML][HTML] The functional organization of excitatory synaptic input to place cells
… j Percentage of ROIs in each ROI category for place vs nonplace cells. Each circle represents
a single branch. Mean ± bci … Source data are provided as a Source Data file for panels (j–l). …
a single branch. Mean ± bci … Source data are provided as a Source Data file for panels (j–l). …
[PDF][PDF] Behavior determines the hippocampal spatial mapping of a multisensory environment
Animals behave in multisensory environments guided by various modalities of spatial
information. Mammalian navigation engages a cognitive map of space in the hippocampus. Yet it …
information. Mammalian navigation engages a cognitive map of space in the hippocampus. Yet it …
[HTML][HTML] A Conserved Dopamine-Cholecystokinin Signaling Pathway Shapes Context–Dependent Caenorhabditis elegans Behavior
An organism's ability to thrive in changing environmental conditions requires the capacity for
making flexible behavioral responses. Here we show that, in the nematode Caenorhabditis …
making flexible behavioral responses. Here we show that, in the nematode Caenorhabditis …
Grid cell spatial tuning reduced following systemic muscarinic receptor blockade
Grid cells of the medial entorhinal cortex exhibit a periodic and stable pattern of spatial
tuning that may reflect the output of a path integration system. This grid pattern has been …
tuning that may reflect the output of a path integration system. This grid pattern has been …
A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans
…, HA Prescott, P Boyle, J Climer… - Journal of …, 2010 - Soc Neuroscience
Inappropriate or excessive activation of ionotropic receptors can have dramatic consequences
for neuronal function and, in many instances, leads to cell death. In Caenorhabditis …
for neuronal function and, in many instances, leads to cell death. In Caenorhabditis …
Precise spike timing dynamics of hippocampal place cell activity sensitive to cholinergic disruption
New memory formation depends on both the hippocampus and modulatory effects of
acetylcholine. The mechanism by which acetylcholine levels in the hippocampus enable new …
acetylcholine. The mechanism by which acetylcholine levels in the hippocampus enable new …