[HTML][HTML] Contulakin-G, an O-glycosylated invertebrate neurotensin
…, J Dykert, E Richelson, V Navarro, J Mazella… - Journal of Biological …, 1999 - ASBMB
We have purified contulakin-G, a 16-amino acid O-linked glycopeptide (pGlu-Ser-Glu-Glu-Gly-Gly-Ser-Asn-Ala-Thr-Lys-Lys-Pro-Tyr-Ile-Leu-OH,
pGlu is pyroglutamate) from Conus …
pGlu is pyroglutamate) from Conus …
[HTML][HTML] A New Family of Conus Peptides Targeted to the Nicotinic Acetylcholine Receptor (∗)
In this work, a new family of Conus peptides, the αA-conotoxins, which target the nicotinic
acetylcholine receptor, is defined. The first members of this family have been characterized …
acetylcholine receptor, is defined. The first members of this family have been characterized …
GnRH Antagonists: A New Generation of Long Acting Analogues Incorporating p-Ureido-phenylalanines at Positions 5 and 6
G Jiang, J Stalewski, R Galyean, J Dykert… - Journal of medicinal …, 2001 - ACS Publications
A series of antagonists of gonadotropin-releasing hormone (GnRH) of the general formula
Ac-d2Nal-d4Cpa-d3Pal-Ser-4Aph/4Amf(P)-d4Aph/d4Amf(Q)-Leu-ILys-Pro-dAla-NH 2 was …
Ac-d2Nal-d4Cpa-d3Pal-Ser-4Aph/4Amf(P)-d4Aph/d4Amf(Q)-Leu-ILys-Pro-dAla-NH 2 was …
An O-Glycosylated Neuroexcitatory Conus Peptide
…, J Dykert, JE Rivier, WR Gray, J Imperial… - Biochemistry, 1998 - ACS Publications
We purified and characterized a novel peptide from the venom of the fish-hunting cone snail
Conus striatus that inhibits voltage-gated K + channels. The peptide, κA-conotoxin SIVA, …
Conus striatus that inhibits voltage-gated K + channels. The peptide, κA-conotoxin SIVA, …
[HTML][HTML] A novel post-translational modification involving bromination of tryptophan: identification of the residue, L-6-bromotryptophan, in peptides from Conus …
…, EC Jimenez, J Dykert, DB Nielsen, J Gulyas… - Journal of Biological …, 1997 - ASBMB
We report a novel post-translational modification involving halogenation of tryptophan in
peptides recovered from the venom of carnivorous marine cone snails (Conus). The residue, L-6…
peptides recovered from the venom of carnivorous marine cone snails (Conus). The residue, L-6…
Pharmacological characterization of FE 202158, a novel, potent, selective, and short-acting peptidic vasopressin V1a receptor full agonist for the treatment of …
…, E La, H Tariga, S Alagarsamy, B Ly, J Dykert… - … of Pharmacology and …, 2011 - ASPET
FE 202158, ([Phe 2 ,Ile 3 ,Hgn 4 ,Orn(iPr) 8 ]vasopressin, where Hgn is homoglutamine and
iPr is isopropyl), a peptidic analog of the vasoconstrictor hormone [Arg 8 ]vasopressin (AVP), …
iPr is isopropyl), a peptidic analog of the vasoconstrictor hormone [Arg 8 ]vasopressin (AVP), …
Isolation of Lys-conopressin-G from the venom of the worm-hunting snail, Conus imperialis
DB Nielsen, J Dykert, JE Rivier, JM McIntosh - Toxicon, 1994 - Elsevier
DB Nielsen, J. Dykert, JE Rivier and JM McIntosh. Isolation of Lys-conopressin-G from the
venom of the worm-hunting snail, Conus imperialis. Toxicon32, 845–848, 1994.—Vasopressin …
venom of the worm-hunting snail, Conus imperialis. Toxicon32, 845–848, 1994.—Vasopressin …
Gonadotropin-releasing hormone antagonists with N. omega.-triazolylornithine,-lysine, or-p-aminophenylalanine residues at positions 5 and 6
…, P Theobald, AG Craig, J Dykert… - Journal of medicinal …, 1992 - ACS Publications
In order to be used as fertility regulators in humans, gonadotropin releasing hormone (GnRH)
antagonists must be extremely potent and long acting and exhibit negligible side effects …
antagonists must be extremely potent and long acting and exhibit negligible side effects …
A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor
RW Teichert, J Rivier, J Torres, J Dykert… - Journal of …, 2005 - Soc Neuroscience
We have purified and characterized a novel conotoxin from the venom of Conus obscurus,
which has the unique property of selectively and potently inhibiting the fetal form of the …
which has the unique property of selectively and potently inhibiting the fetal form of the …
αA-Conotoxin OIVA defines a new αA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors
RW Teichert, J Rivier, J Dykert, L Cervini, J Gulyas… - Toxicon, 2004 - Elsevier
The venoms of cone snails are rich in multiply disulfide-crosslinked peptides, the conotoxins.
Conotoxins are grouped into families on the basis of shared cysteine patterns and …
Conotoxins are grouped into families on the basis of shared cysteine patterns and …