Macroscopic membraneless organelles containing RNA such as the nucleoli, germ granules,
and the Cajal body have been known for decades. These biomolecular condensates are …

Regulation of biological processes typically incorporates mechanisms that initiate and terminate
the process and, where understood, these mechanisms often involve feedback control. …

The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a
transcription initiation complex, and a transition to an elongation complex 1 , 2 , 3 – 4 . The large …

… J Henninger helped in the cloning, sequencing, and antigen purification. J Herkel helped
with the immunoblotting, data analysis, and writing. S Kanzler helped in collecting patient …

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …

The nucleus contains diverse phase-separated condensates that compartmentalize and
concentrate biomolecules with distinct physicochemical properties. Here, we investigated …

Transforming growth factor-β1 (TGF-β1) is a powerful stimulus for collagen formation in vitro.
To determine the in vivo effects of TGF-β1 on liver fibrogenesis, we generated transgenic …

Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and
progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique that …

The gene expression programs that define the identity of each cell are controlled by master
transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, …

Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin,
which is crucial for chromosome maintenance and transcriptional silencing 1 , 2 – 3 . …