Of paramount importance for the development of cell therapies to treat diabetes is the production
of sufficient numbers of pancreatic endocrine cells that function similarly to primary islets…

… Kevin A D'Amour … Lawson, KA et al. Bmp4 is required for the generation of primordial
germ cells in the mouse embryo. Genes Dev. … Kevin A D'Amour …

Abstract Development of a cell therapy for diabetes would be greatly aided by a renewable
supply of human β-cells. Here we show that pancreatic endoderm derived from human …

The potential of pluripotent human cells, such as human embryonic stem cells (hESCs) and
induced pluripotent stem (iPS) cells, to differentiate into any adult cell type makes them …

To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed
Sox2-GFP transgenic mice. Sox2-GFP cells in the subgranular zone (SGZ) express …

Human ESCs (hESCs) respond to signals that determine their pluripotency, proliferation,
survival, and differentiation status. In this report, we demonstrate that phosphatidylinositol 3-…

Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will
require the translation of proof-of-principle concepts into a scalable, controlled, and …

These preliminary data from an ongoing first-in-human phase 1/2, open-label study provide
proof-of-concept that pluripotent stem cell-derived pancreatic endoderm cells (PEC-01) …

Using a flow cytometry–based screen of commercial antibodies, we have identified cell-surface
markers for the separation of pancreatic cell types derived from human embryonic stem (…

Somatic stem cells have been claimed to possess an unexpectedly broad differentiation
potential (referred to here as plasticity) that could be induced by exposing stem cells to the …