User profiles for K. L. Eckel-Mahan
Kristin Eckel MahanUniversity of Texas Health Science Center at Houston Verified email at uth.tmc.edu Cited by 6274 |
[HTML][HTML] Reprogramming of the circadian clock by nutritional challenge
Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-fat
diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …
diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …
Coordination of the transcriptome and metabolome by the circadian clock
KL Eckel-Mahan, VR Patel… - Proceedings of the …, 2012 - National Acad Sciences
The circadian clock governs a large array of physiological functions through the transcriptional
control of a significant fraction of the genome. Disruption of the clock leads to metabolic …
control of a significant fraction of the genome. Disruption of the clock leads to metabolic …
[HTML][HTML] Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock
…, F Solagna, M Albiero, I Moretti, KL Eckel-Mahan… - Molecular …, 2014 - Elsevier
Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal
muscle clock has never been explored. We generated conditional and inducible mouse lines …
muscle clock has never been explored. We generated conditional and inducible mouse lines …
Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence
The mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate (cAMP)
signal transduction pathways have critical roles in the consolidation of hippocampus-…
signal transduction pathways have critical roles in the consolidation of hippocampus-…
[PDF][PDF] Distinct circadian signatures in liver and gut clocks revealed by ketogenic diet
The circadian clock orchestrates rhythms in physiology and behavior, allowing organismal
adaptation to daily environmental changes. While food intake profoundly influences diurnal …
adaptation to daily environmental changes. While food intake profoundly influences diurnal …
Circadian acetylome reveals regulation of mitochondrial metabolic pathways
S Masri, VR Patel, KL Eckel-Mahan… - Proceedings of the …, 2013 - National Acad Sciences
The circadian clock is constituted by a complex molecular network that integrates a number
of regulatory cues needed to maintain organismal homeostasis. To this effect, …
of regulatory cues needed to maintain organismal homeostasis. To this effect, …
Gut microbiota directs PPAR γ‐driven reprogramming of the liver circadian clock by nutritional challenge
The liver circadian clock is reprogrammed by nutritional challenge through the rewiring of
specific transcriptional pathways. As the gut microbiota is tightly connected to host metabolism, …
specific transcriptional pathways. As the gut microbiota is tightly connected to host metabolism, …
Cycling behavior and memory formation
Circadian research has spent considerable effort in the determining clock output pathways,
including identifying both physiological and behavioral processes that demonstrate …
including identifying both physiological and behavioral processes that demonstrate …
Circadian rhythms and memory: not so simple as cogs and gears
KL Eckel‐Mahan, DR Storm - EMBO reports, 2009 - embopress.org
The influence of circadian rhythms on memory has long been studied; however, the molecular
prerequisites for their interaction remain elusive. The hippocampus, which is a region of …
prerequisites for their interaction remain elusive. The hippocampus, which is a region of …
Selective Kv1. 3 channel blocker as therapeutic for obesity and insulin resistance
SK Upadhyay, KL Eckel-Mahan… - Proceedings of the …, 2013 - National Acad Sciences
Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1.3 channel, …
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1.3 channel, …