Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-fat
diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …

The circadian clock governs a large array of physiological functions through the transcriptional
control of a significant fraction of the genome. Disruption of the clock leads to metabolic …

Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal
muscle clock has never been explored. We generated conditional and inducible mouse lines …

The mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate (cAMP)
signal transduction pathways have critical roles in the consolidation of hippocampus-…

The circadian clock orchestrates rhythms in physiology and behavior, allowing organismal
adaptation to daily environmental changes. While food intake profoundly influences diurnal …

The circadian clock is constituted by a complex molecular network that integrates a number
of regulatory cues needed to maintain organismal homeostasis. To this effect, …

The liver circadian clock is reprogrammed by nutritional challenge through the rewiring of
specific transcriptional pathways. As the gut microbiota is tightly connected to host metabolism, …

Circadian research has spent considerable effort in the determining clock output pathways,
including identifying both physiological and behavioral processes that demonstrate …

The influence of circadian rhythms on memory has long been studied; however, the molecular
prerequisites for their interaction remain elusive. The hippocampus, which is a region of …

Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1.3 channel, …