User profiles for K. Keinänen
Kari KeinänenUniversity of Helsinki Verified email at helsinki.fi Cited by 10379 |
Biosynthetic lipid‐tagging of antibodies
K Keinänen, ML Laukkanen - FEBS letters, 1994 - Wiley Online Library
Chemical conjugation of fatty acids to antibodies generates lipid‐modified molecules which
have found use in the targeting of liposome‐mediated drug delivery and in liposome‐based …
have found use in the targeting of liposome‐mediated drug delivery and in liposome‐based …
A family of AMPA-selective glutamate receptors
K Keinänen, W Wisden, B Sommer, P Werner, A Herb… - Science, 1990 - science.org
Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with
approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ …
approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ …
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
B Sommer, K Keinänen, TA Verdoorn, W Wisden… - Science, 1990 - science.org
In the central nervous system (CNS), the principal mediators of fast synaptic excitatory
neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate …
neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate …
Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells
… Hence, KA-1 has marked differences in its pharmacology to either the chick KBP (K, for …
had a K, of 40 nM at KA-1, markedly lower than the K, of 1,5 nM for the kainate site with a K, …
had a K, of 40 nM at KA-1, markedly lower than the K, of 1,5 nM for the kainate site with a K, …
[HTML][HTML] KCC2 interacts with the dendritic cytoskeleton to promote spine development
The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render
GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, …
GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, …
Cerebellar GABAA receptor selective for a behavioural alcohol antagonist
…, DB Pritchett, M Köhler, I Killisch, K Keinänen… - Nature, 1990 - nature.com
… K, values for the latter receptors are from ref. 12. K, values were calculated according to
the Cheng-Prusoff equation. ND, not determined. Methods were as described previously"*", (b) …
the Cheng-Prusoff equation. ND, not determined. Methods were as described previously"*", (b) …
A glutamate receptor channel with high affinity for domoate and kainate.
…, N Burnashev, TA Verdoorn, K Keinänen… - The EMBO …, 1992 - embopress.org
The non‐NMDA family of glutamate receptors comprises a growing number of structurally
related subunits (GluR‐A to ‐D or −1 to −4; GluR‐5, −6; KA‐1). GluR‐A to ‐D appear to …
related subunits (GluR‐A to ‐D or −1 to −4; GluR‐5, −6; KA‐1). GluR‐A to ‐D appear to …
Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors
…, U Koehl, ICD Johnston, K Keinänen… - Nature …, 2010 - nature.com
We present a flexible and highly specific targeting method for lentiviral vectors based on
single-chain antibodies recognizing cell-surface antigens. We generated lentiviral vectors …
single-chain antibodies recognizing cell-surface antigens. We generated lentiviral vectors …
Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor α4 subunit
W Wisden, A Herb, H Wieland, K Keinänen… - FEBS …, 1991 - Wiley Online Library
A cDNA of rat brain encoding the GABA A receptor α 4 subunit has been cloned. Recombinant
receptors composed of α 4 , β 2 and γ 2 subunits bind with high affinity the GABA agonist [ …
receptors composed of α 4 , β 2 and γ 2 subunits bind with high affinity the GABA agonist [ …
Molecular dissection of the agonist binding site of an AMPA receptor.
A Kuusinen, M Arvola, K Keinänen - The EMBO journal, 1995 - embopress.org
Two discontinuous segments (S1 and S2), separated by membrane‐associated domains, in
ionotropic glutamate receptor (GluR) subunits show sequence similarity to bacterial …
ionotropic glutamate receptor (GluR) subunits show sequence similarity to bacterial …