… Loren Walensky became the chemistry and biology bridge for a Korsmeyer–Verdine
collaboration on generating hydrocarbon-stapled BH3 peptide helices. We found that hydrocarbon …

… We thank the members of the Verdine and Walensky laboratories, past and present, for their
numerous contributions, and John Quackenbush for an informative analysis of extracellular …

The discovery of B-cell lymphoma-2 (BCL-2) over 20 years ago revealed a new paradigm in
cancer biology: the development and persistence of cancer can be driven by molecular …

The "BH3-only" proteins of the BCL-2 family require "multidomain" proapoptotic members
BAX and BAK to release cytochrome c from mitochondria and kill cells. We find short peptides …

BCL-2 family proteins constitute a critical control point for the regulation of apoptosis. Protein
interaction between BCL-2 members is a prominent mechanism of control and is mediated …

BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated
by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such as BCL-2 …

The p53-hDM2 protein interaction is a validated therapeutic target in cancer. We report the
synthesis of stabilized alpha-helix of p53 (SAH-p53) compounds that antagonize the p53-…

BAX is a multidomain proapoptotic BCL-2 family protein that resides in the cytosol until
activated by an incompletely understood trigger mechanism, which facilitates BAX translocation …

The development of selective inhibitors for discrete anti-apoptotic BCL-2 family proteins
implicated in pathologic cell survival remains a formidable but pressing challenge. Such …

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial
advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by …