Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …

This paper describesstudies qf the formation of self-assembled monolayers (SAMs) and
multilayers on gold surfaces of rigid-rod conjugated oligomers that have thiol,,-dithiol, thioacetyl, …

… , and LRJones, unpublished data) activities by monitoring both ATP hydrolysis and calcium
transport by the enzymes. Similar lack of effect of high concentrations of a synthetic peptide …

… and is the major 125 I-calsequestrin-binding protein detected in cardiac sarcoplasmic
reticulum vesicles (Jones, LR, Zhang, L., Sanborn, K., Jorgensen, AO, and Kelley, J. (1995)J. Biol. …

Ryanodine receptors have recently been shown to be the Ca2+ release channels of
sarcoplasmic reticulum in both cardiac muscle and skeletal muscle. Several regulatory sites are …

Phospholamban is a regulatory protein in cardiac sarcoplasmic reticulum that is phosphorylated
by cAMP- and Ca2+/calmodulin-dependent protein kinase activities. In this report, we …

The level of Ca inside the sarcoplasmic reticulum (SR) is an important determinant of functional
activity of the Ca release channel/ryanodine receptor (RyR) in cardiac muscle. However, …

Cardiac calsequestrin (Casq2) is thought to be the key sarcoplasmic reticulum (SR) Ca 2+
storage protein essential for SR Ca 2+ release in mammalian heart. Human CASQ2 mutations …

The ability of a drug or probe to cross a biological barrier has historically been viewed to be
a function of its intrinsic physical properties. This view has largely restricted drug design and …

Phospholamban is the major membrane protein of the heart phosphorylated in response to
β-adrenergic stimulation. In cell-free systems, cAMP-dependent protein kinase catalyzes …