Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual
to develop cardiometabolic diseases, such as type 2-diabetes mellitus and atherosclerosis…

Cholesterol homeostasis is among the most intensely regulated processes in biology. Since
its isolation from gallstones at the time of the French Revolution, cholesterol has been …

Circulating levels of low-density lipoprotein cholesterol (LDL), and high-density lipoprotein
cholesterol (HDL) are two of the most important risk factors for the development of …

Cardiovascular disease remains the leading cause of mortality in westernized countries,
despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-…

Cellular imbalances of cholesterol and fatty acid metabolism result in pathological processes,
including atherosclerosis and metabolic syndrome. Recent work from our group and …

The amygdala is a key region for the processing of information underlying fear, anxiety, and
fear extinction. Within the local neuronal networks of the amygdala, a population of inhibitory…

Cyclic pentapeptides (eg Ac‐(cyclo‐1,5)‐[KAXAD]‐NH 2 ; X=Ala, 1; Arg, 2) in water adopt
one α‐helical turn defined by three hydrogen bonds. NMR structure analysis reveals a slight …

Genome-wide association studies (GWASs) have linked genes to various pathological traits.
However, the potential contribution of regulatory noncoding RNAs, such as microRNAs (…

Objective— The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of macrophage
cholesterol efflux and protects cells from excess intracellular cholesterol accumulation…

The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing
circulating LDL cholesterol (LDL-C). Whereas the transcriptional regulation of LDLR is well …