… Inhibitors of the bovine heart enzyme, β-methylene-d,l-aspartate or d,l-vinylglycine, were
without effect on the brain mitochondrial α-KGDH but l-aspartate, which did not influence the …

Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is becoming …

Oxidative stress and partial deficiencies of mitochondrial complex I appear to be key factors
in the pathogenesis of Parkinson's disease. They are interconnected; complex I inhibition …

Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive
drug target in numerous maladies that range from heart disease to neurodegenerative …

α-Ketoglutarate dehydrogenase (α-KGDH), a key enzyme in the Krebs' cycle, is a crucial early
target of oxidative stress ( Tretter and Adam-Vizi, 2000 ). The present study demonstrates …

In this study we addressed the function of the Krebs cycle to determine which enzyme(s)
limits the availability of reduced nicotinamide adenine dinucleotide (NADH) for the respiratory …

Background and Purpose Elevated energy costs of hemiparetic gait contribute to functional
disability after stroke, particularly in physically deconditioned older patients. We investigated …

In this study reactive oxygen species (ROS) generated in the respiratory chain were measured
and the quantitative relationship between inhibition of the respiratory chain complexes …

Background and Purpose Coronary artery disease is prevalent in stroke patients and is an
important factor affecting rehabilitation and health outcomes. However, the presence of …

Itaconate is a nonamino organic acid exhibiting antimicrobial effects. It has been recently
identified in cells of macrophage lineage as a product of an enzyme encoded by …