Cellular responses to metabotropic glutamate (mGlu) receptor activation are shaped by
mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers, intra- or …

This review is an introduction to addiction, the reward circuitry, and laboratory addiction
models. Addiction is a chronic disease hallmarked by a state of compulsive drug seeking that …

Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range neural …

Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited
understanding of the molecular and experience-dependent mechanisms that regulate synaptic …

mGlu5 receptors are involved in mechanisms of activity-dependent synaptic plasticity, and
are targeted by drugs developed for the treatment of CNS disorders. We report that mGlu3 …

… Joffe et al. leverage optimized negative allosteric modulators to interrogate the underlying
neurocircuits, discovering that selective inhibition of either mGlu2 or mGlu3 enhances …

At the core of value-based learning is the nucleus accumbens (NAc). D1- and D2-receptor-containing
medium spiny neurons (MSNs) in the NAc core are hypothesized to have …

Stress can precipitate or worsen symptoms of many psychiatric illnesses. Dysregulation of
the prefrontal cortex (PFC) glutamate system may underlie these disruptions and restoring …

Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be
particularly susceptible to cravings and other components of the disease. While many brain …

Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent
findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest that …