The central roles of salt (NaCl) and the kidneys in the pathogenesis of most forms of hypertension
are well established. 1, 2 The linkage between NaCl retention and blood pressure (BP…

This article reviews genetically encoded Ca 2+ indicators (GECIs), with a focus on the use of
these novel molecules in the context of understanding complex cell signalling in mammals, …

Transplantation studies in mice and rats have shown that human embryonic-stem-cell-derived
cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts 1 , 2 , 3 , but two …

Major features of the transcellular signaling mechanism responsible for endothelium-dependent
regulation of vascular smooth muscle tone are unresolved. We identified local calcium (…

Genetically encoded sensor proteins provide unique opportunities to advance the
understanding of complex cellular interactions in physiologically relevant contexts; however, …

This review summarizes recent data on the two specific mechanisms of p-adrenergic relaxation
of airway smooth muscle. B2-adrenergic receptor stimulation results in the opening of …

Ventricular tachyarrhythmias are the main cause of sudden death in patients after myocardial
infarction. Here we show that transplantation of embryonic cardiomyocytes (eCMs) in …

We report the development of a nontransformed line of human airway smooth muscle cells
retaining smooth muscle-specific contractile protein expression and physiological …

FK506 binding proteins 12 and 12.6 (FKBP12 and FKBP12.6) are intracellular receptors for
the immunosuppressant drug FK506 (ref. 1 ). The skeletal muscle ryanodine receptor (RyR1) …

… Tomasic, and MI Kotlikoff. 1992. Delayed rectifier potassium channels in canine and porcine
… Kotlikoff, MI 1988. Calcium currents in isolated canine airway smooth muscle cells. Am. …