Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune
encephalomyelitis, implicate a novel CD4 + T-cell subset (T H 17), characterized by the …

Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration 1 , 2
. The neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1) 3 , 4 is …

Following the loss of myelin from axons in multiple sclerosis, some axons recover the ability
to conduct impulses despite the absence of an insulating sheath, providing a basis for …

Although voltage-gated sodium channels are known to be deployed along experimentally
demyelinated axons, the molecular identities of the sodium channels expressed along axons …

Spinal cord injury (SCI) can result in hyperexcitability of dorsal horn neurons and central
neuropathic pain. We hypothesized that these phenomena are consequences, in part, of …

Treatments with a range of efficacy and risk of adverse events have become available for
the management of multiple sclerosis (MS). However, now the heterogeneity of clinical …

Peripheral nerve injury is known to upregulate the rapidly repriming Na v 1.3 sodium
channel within first-order spinal sensory neurons. In this study, we hypothesized that (1) after …

Loss of axons is a major contributor to nonremitting deficits in the inflammatory demyelinating
disease multiple sclerosis (MS). Based on biophysical studies showing that activity of …

Axonal degeneration contributes to the development of non‐remitting neurological deficits
and disability in multiple sclerosis, but the molecular mechanisms that underlie axonal loss in …

Although pain is experienced by many patients with diabetic neuropathy, the pathophysiology
of painful diabetic neuropathy is not understood. Substantial evidence indicates that …