Flow cytometry is used extensively to examine immune cells in non-lymphoid tissues. However,
a method of flow cytometric analysis that is both comprehensive and widely applicable …

The testis produces sperm throughout the male reproductive lifespan by balancing self-renewal
and differentiation of spermatogonial stem cells (SSCs). Part of the SSC niche is thought …

Macrophages and dendritic cells (DC) are distributed throughout the body and play important
roles in pathogen detection and tissue homeostasis. In tissues, resident macrophages …

The pathogenesis of Alzheimer9s disease (AD) is a critical unsolved question; and although
recent studies have demonstrated a strong association between altered brain immune …

Strategies that enhance the host antitumor immune response promise to revolutionize
cancer therapy. Optimally mobilizing the immune system will likely require a multi-pronged …

Inappropriate activation of the renin angiotensin system (RAS) is a key contributor to the
pathogenesis of essential hypertension. During RAS activation, infiltration of immune cells into …

There is increasing appreciation that the immune system plays critical roles not only in the
traditional domains of infection and inflammation but also in many areas of biology, including …

An increasing body of evidence suggests that bone marrow–derived myeloid cells play a
critical role in the pathophysiology of pulmonary hypertension (PH). However, the true …

CRISPR-Cas enzymes enable RNA-guided bacterial immunity and are widely used for
biotechnological applications including genome editing. In particular, the Class 2 CRISPR-…

In nature, microorganisms use CRISPR (clustered regularly interspaced palindromic repeats)
and CRISPR-associated (Cas) proteins for antiviral immunity through recognition and …