Although the synthesis and metabolism of plasma lipoproteins are well characterized, little
is known about lipid delivery and clearance within the central nervous system (CNS). Our …

Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ) contribute
to Alzheimer's disease ( AD ) pathology. APOE 4 is the greatest AD ‐genetic risk factor; …

In the past five years, a series of large-scale genetic studies have revealed novel risk factors
for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the …

Genetic evidence predicts a causative role for amyloid-β (Aβ) in Alzheimer's disease. Recent
debate has focused on whether fibrils (amyloid) or soluble oligomers of Aβ are the active …

Extensive research causally links amyloid-β peptide (Aβ) to Alzheimer's disease, although
the pathologically relevant Aβ conformation remains unclear. Aβ spontaneously aggregates …

Apolipoprotein E (apoE), particularly the e4 allele, is genetically linked to the incidence of
Alzheimer's disease. ApoE is present in the extracellular senile plaques and intracellular …

This chapter outlines protocols that produce homogenous preparations of oligomeric and
fibrillar amyloid-β peptide (Aβ). While there are several isoforms of this peptide, the 42 amino …

Little is known about lipid transport and metabolism in the brain. As a further step toward
understanding the origin and function of CNS lipoproteins, we have characterized by size and …

The inheritance of the apolipoprotein E (apoE) ϵ4 allele is a prevailing risk factor for sporadic
and familial Alzheimer's disease (AD). ApoE isoforms bind directly to Alzheimer's amyloid …

Activated glia, as a result of chronic inflammation, are associated with amyloid-β peptide (Aβ)
deposits in the brain of Alzheimer's disease (AD) patients. In vitro, glia are activated by Aβ …