… Protein A-Sepharose then was pelleted by centrifugation and washed three times with cold
radioimmunoprecipitation buffer (20 mM Tris-HCl [pH 7.5], 150 mM NaCl, 1% Triton X-100, 1…

More than 10 10 cells are generated every day in the human intestine. Wnt proteins are key
regulators of proliferation and are known endogenous mitogens for intestinal progenitor cells…

Ryk (receptor related to tyrosine kinase) has been shown to be a novel Wnt receptor in both
Caenorhabditis elegans and Drosophila melanogaster. Recently, Ryk–Wnt interactions …

Secondary palate formation is a complex process that is frequently disturbed in mammals,
resulting in the birth defect cleft palate 1, 2. Gene targeting has identified components of …

Signaling proteins driving the proliferation of stem and progenitor cells are often encoded by
proto-oncogenes. EphB receptors represent a rare exception; they promote cell proliferation …

The receptor tyrosine kinases (RTKs) are a well-characterized family of growth factor receptors
that have central roles in human disease and are frequently therapeutically targeted. The …

The Wnt signaling pathways control many critical developmental and adult physiological
processes. In vertebrates, one fundamentally important function of Wnts is to provide directional …

Wnts are essential for a wide range of developmental processes, including cell growth,
division, and differentiation. Some of these processes signal via the planar cell polarity (PCP) …

Significant progress has been made over the last decade in elucidating the mechanisms
employed by receptor protein tyrosine kinases (RTKs) in transducing extracellular signals …

The secreted glycoprotein vascular endothelial growth factor-D (VEGF-D) is angiogenic,
lymphangiogenic, and promotes metastatic spread of tumor cells via lymphatic vessels. VEGF-D …