Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury

…, S Erbayraktar, M Akhisaroglu… - Proceedings of the …, 2002 - National Acad Sciences
The cytokine erythropoietin (EPO) possesses potent neuroprotective activity against a
variety of potential brain injuries, including transient ischemia and reperfusion. It is currently …

DAMP signaling is a key pathway inducing immune modulation after brain injury

…, W Zhou, H Yang, SY Na, M Akhisaroglu… - Journal of …, 2015 - Soc Neuroscience
… used at a concentration of 100 nm by adding the stimulus directly into the culture medium. …
animals 3 d after MCAO were stimulated with 1 μm CpG-ODN overnight, and IL12p40 and TNF…

The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system

…, AD Arslan, M Kurtuncu, M Imbesi, M Akhisaroglu… - Molecular brain …, 2005 - Elsevier
The physiological effects of pineal melatonin are primarily mediated by melatonin receptors
located in the brain and periphery. Even though there are a number of studies demonstrating …

Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats

A Kumral, E Ozer, O Yilmaz, M Akhisaroglu, N Gokmen… - Neonatology, 2003 - karger.com
Erythropoietin (Epo) prevents ischemia and hypoxia-induced neuronal death in vitro. Recent
studies have shown that this cytokine also has in vivo neuroprotective effects in cerebral …

Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum

T Uz, R Ahmed, M Akhisaroglu, M Kurtuncu, M Imbesi… - Neuroscience, 2005 - Elsevier
Long-term drug-induced alterations in CNS gene expression may be responsible for some
therapeutic effects, such as antidepressant action, as well as for psychopathological …

Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine …

S Genc, M Akhisaroglu, F Kuralay, K Genc - Neuroscience letters, 2002 - Elsevier
Recently, we have reported that erythropoietin (Epo) provides neuroprotection in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
(MPTP)-induced neurotoxicity in vivo. In the present study…

[HTML][HTML] The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice

T Uz, M Akhisaroglu, R Ahmed, H Manev - Neuropsychopharmacology, 2003 - nature.com
Sensitization to psychostimulants can be influenced by circadian rhythms. The pineal gland,
the main source of circadian melatonin synthesis, may influence behavioral sensitization to …

Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production

S Genc, F Kuralay, K Genc, M Akhisaroglu… - Neuroscience …, 2001 - Elsevier
Erythropoietin (EPO), produced by the kidney and fetal liver, is a cytokine-hormone that
stimulates erythropoiesis under hypoxic conditions. It has been shown that EPO is produced in …

Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic–ischemic brain injury

A Aydin, K Genc̨, M Akhisaroglu, K Yorukoglu… - Brain and …, 2003 - Elsevier
Hypoxic–ischemic encephalopathy seen in survivors of perinatal asphyxia is a frequently
encountered and a major clinical problem for which there is currently no effective treatment. …

[HTML][HTML] Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in …

…, P Beckhove, M Akhisaroglu, Y Ge, M Springer… - BMC cancer, 2012 - Springer
… The vaccine is assumed to lead to VEGFR-2 protein expression in monocytes and dendritic
cells after entry of VXM01 in the Peyer’s patches via M cells of the gut, and internalization by …