Distinct mechanism for antidepressant activity by blockade of central substance P receptors
…, T Harrison, RG Hill, F Hefti, EM Scolnick, MA Cascieri… - Science, 1998 - science.org
The localization of substance P in brain regions that coordinate stress responses and receive
convergent monoaminergic innervation suggested that substance P antagonists might …
convergent monoaminergic innervation suggested that substance P antagonists might …
Receptor for motilin identified in the human gastrointestinal system
…, MA Cascieri, R Nargund, R Bakshi, M Abramovitz… - Science, 1999 - science.org
Motilin is a 22–amino acid peptide hormone expressed throughout the gastrointestinal (GI)
tract of humans and other species. It affects gastric motility by stimulating interdigestive …
tract of humans and other species. It affects gastric motility by stimulating interdigestive …
Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression
…, R Meurer, MJ Forrest, MW Conner, MA Cascieri… - …, 1998 - academic.oup.com
… 50 mm Tris (pH 7.2), 10% glycerol, 0.2 mm EDTA, 0.5 mm dithiothreitol,
phenylmethlysulfonylflouride (75 μg/ml), and leupeptin (1 μg/ml). The solution was adjusted to …
phenylmethlysulfonylflouride (75 μg/ml), and leupeptin (1 μg/ml). The solution was adjusted to …
The chemokine/chemokine-receptor family: potential and progress for therapeutic intervention
MA Cascieri, MS Springer - Current Opinion in Chemical Biology, 2000 - Elsevier
The chemokines are a large superfamily of chemotactic cytokines that are utilized to direct
the trafficking and migration of leukocytes within the immune system. The chemokines …
the trafficking and migration of leukocytes within the immune system. The chemokines …
Human β3-adrenergic receptor agonists containing 1, 2, 3-triazole-substituted benzenesulfonamides
…, HO Ok, MR Candelore, MA Cascieri… - Bioorganic & medicinal …, 2000 - Elsevier
Compounds containing a 1,2,3-triazole-substituted benzenesulfonamide were prepared
and found to be potent and selective human β 3 -adrenergic receptor agonists. The most …
and found to be potent and selective human β 3 -adrenergic receptor agonists. The most …
Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets
…, L Keown, C Swain, R Baker, M Cascieri… - …, 1996 - Elsevier
These studies have compared the pharmacological profile of two non-peptide human type
neurokinin 1 (hNK 1 ) receptor selective antagonists, L-741,671 and a quaternised compound …
neurokinin 1 (hNK 1 ) receptor selective antagonists, L-741,671 and a quaternised compound …
Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent …
…, M MacCoss, PE Finke, MA Cascieri… - Journal of medicinal …, 1998 - ACS Publications
Structural modifications requiring novel synthetic chemistry were made to the morpholine
acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2…
acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2…
Azasteroids: structure-activity relationships for inhibition of 5. alpha.-reductase and of androgen receptor binding
…, E Walton, GF Patel, T Liang, MA Cascieri… - Journal of medicinal …, 1986 - ACS Publications
A series of steroids, primarily 4-azasteroids, were prepared and tested in vitro as inhibitors
of human and rat prostatic 5a-reductase and of binding ofdihydrotestosterone to the rat …
of human and rat prostatic 5a-reductase and of binding ofdihydrotestosterone to the rat …
Potent, orally absorbed glucagon receptor antagonists
…, JV Pivnichny, L Colwell, GE Koch, MA Cascieri… - Bioorganic & medicinal …, 1999 - Elsevier
… 9 Condensation of the silyl acyloin A with an acetophenone B provided low yields of the
pyrroles C in a one pot reaction.m A higher yielding route was developed from the 4-…
pyrroles C in a one pot reaction.m A higher yielding route was developed from the 4-…
[HTML][HTML] Cloning and expression of a novel neuropeptide Y receptor
…, DR Rapoport, ML Bayne, MA Cascieri… - Journal of Biological …, 1996 - ASBMB
… 0.5 M potassium cacodylate (pH 7.2), 10 mM cobalt chloride, and 1.0 mM dithiothreitol. …
mM sodium phosphate, pH 7.0, 1 mM sodium pyrophosphate, 10% dextran sulfate, and 40 …
mM sodium phosphate, pH 7.0, 1 mM sodium pyrophosphate, 10% dextran sulfate, and 40 …