[PDF][PDF] Identification and Characterization of an Irreversible Inhibitor of CDK2
…, R Mora-Vidal, MP Martin, D Staunton, M Geitmann… - Chemistry & biology, 2015 - cell.com
… The resultant m/z spectra were converted to mass spectra by using the maximum entropy …
reaction velocity of 5.98 x 10-14 Ms-1 from which akinact of 4.98 x 103 M-1.s-1 was calculated. …
reaction velocity of 5.98 x 10-14 Ms-1 from which akinact of 4.98 x 103 M-1.s-1 was calculated. …
Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora
K Sookkongwaree, M Geitmann… - Die Pharmazie-An …, 2006 - ingentaconnect.com
In order to identify novel lead compounds with antiviral effect, methanol and aqueous
extracts of eight medicinal plants in the Zingiberaceae family were screened for inhibition of …
extracts of eight medicinal plants in the Zingiberaceae family were screened for inhibition of …
A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
…, T Conze, W Witt, C Limbach, M Geitmann… - Journal of …, 2009 - Soc Neuroscience
Multidomain scaffolding proteins organize the molecular machinery of neurotransmitter vesicle
dynamics during synaptogenesis and synaptic activity. We find that domains of five active …
dynamics during synaptogenesis and synaptic activity. We find that domains of five active …
Structural basis of ligand recognition in 5‐HT3 receptors
…, M Brams, R Van Elk, R Spurny, M Geitmann… - EMBO …, 2013 - embopress.org
The 5‐HT 3 receptor is a pentameric serotonin‐gated ion channel, which mediates rapid
excitatory neurotransmission and is the target of a therapeutically important class of anti‐emetic …
excitatory neurotransmission and is the target of a therapeutically important class of anti‐emetic …
Structural and functional analysis of hepatitis C virus strain JFH1 polymerase
P Simister, M Schmitt, M Geitmann, O Wicht… - Journal of …, 2009 - Am Soc Microbiol
… The reactions were terminated by the addition of 1 volume of 0.5 M EDTA. Processivity and
… The surfaces could effectively be regenerated by injections of 2 M NaCl and 2 M MgCl. …
… The surfaces could effectively be regenerated by injections of 2 M NaCl and 2 M MgCl. …
Development of (4-cyanophenyl) glycine derivatives as reversible inhibitors of lysine specific demethylase 1
…, S Cartic, AM Jordan, M Geitmann… - Journal of Medicinal …, 2017 - ACS Publications
Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differentiation
of leukemia stem cells in acute myeloid leukemia (AML). Irreversible inhibitors developed …
of leukemia stem cells in acute myeloid leukemia (AML). Irreversible inhibitors developed …
Studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology
M Geitmann, UH Danielson - Analytical biochemistry, 2004 - Elsevier
… a lower K m value, resulting in an eightfold higher k cat /K m for the … K m only slightly.
Remarkably, no proteolytic activity was detected with the crosslinked HCMV, whereas the k cat /K m …
Remarkably, no proteolytic activity was detected with the crosslinked HCMV, whereas the k cat /K m …
Macrocyclic peptides uncover a novel binding mode for reversible inhibitors of LSD1
…, S Peintner, C Rhee, V Poongavanam, M Geitmann… - ACS …, 2020 - ACS Publications
Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme which regulates the methylation
of Lys4 of histone 3 (H3) and is overexpressed in certain cancers. We used structures of …
of Lys4 of histone 3 (H3) and is overexpressed in certain cancers. We used structures of …
Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein
M Geitmann, K Retra, GE de Kloe, E Homan… - Biochemistry, 2010 - ACS Publications
… for acetylcholine was simulated using the estimated affinity (K D = 458 nM, Table 1) and a
mass transport constant typically obtained in this study for nicotine (k t = 5 × 10 6 RU M −1 ms −…
mass transport constant typically obtained in this study for nicotine (k t = 5 × 10 6 RU M −1 ms −…
Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening
M Geitmann, M Elinder, C Seeger… - Journal of medicinal …, 2011 - ACS Publications
A novel scaffold inhibiting wild type and drug resistant variants of human immunodeficiency
virus type 1 reverse transcriptase (HIV-1RT) has been identified in a library consisting of …
virus type 1 reverse transcriptase (HIV-1RT) has been identified in a library consisting of …