[HTML][HTML] Evidence for selection of multi-resistant E. coli by hospital effluent

…, K Schumacher, DA Gray, M Genheden… - Environment …, 2021 - Elsevier
There is a risk that residues of antibiotics and other antimicrobials in hospital and municipal
wastewaters could select for resistant bacteria. Still, direct experimental evidence for …

BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1

M Genheden, JW Kenney, HE Johnston… - Journal of …, 2015 - Soc Neuroscience
… BDNF in the presence of 2 mm azidohomoalanine (AHA) for … buffer (8 m urea, 300 mm Tris
pH 8, 4% CHAPS, 1 m NaCI) … mm Tris, pH 8, 1% SDS, 250 mm NaCI, 5 mm EDTA) with 10 …

A Comprehensive Screening of Escherichia coli Isolates from Scandinavia's Largest Sewage Treatment Plant Indicates No Selection for Antibiotic Resistance

CF Flach, M Genheden, J Fick… - … science & technology, 2018 - ACS Publications
There is concern that sewage treatment plants (STPs) serve as hotspots for emergence and
selection of antibiotic resistant bacteria. However, field studies investigating resistance …

Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule‐related proteins in neurons

JW Kenney, M Genheden, KM Moon… - Journal of …, 2016 - Wiley Online Library
… A cut-off of 1 standard deviation above the median M/H ratio was used to define proteins
whose synthesis is most sensitive to eEF2K inhibition as this corresponded to a minimum M/H …

Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity

JW Kenney, O Sorokina, M Genheden… - Journal of …, 2015 - Soc Neuroscience
The rapid regulation of cell signaling in response to calcium in neurons is essential for real-time
processing of large amounts of information in the brain. A vital regulatory component, …

[HTML][HTML] Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents

…, C Cassani, T Olsson, M Genheden… - Beilstein Journal of …, 2019 - beilstein-journals.org
The synthesis and antibacterial activity of two new highly truncated derivatives of the natural
product abyssomicin C are reported. This work outlines the limits of structural truncation of …

Conformational entropies and order parameters: convergence, reproducibility, and transferability

S Genheden, M Akke, U Ryde - Journal of Chemical Theory and …, 2014 - ACS Publications
… The reason for this is that the optimized dictionary parameters (k and m in eq 1) vary …
Samuel Genheden. Effect of solvent model when probing protein dynamics with molecular …

Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3

…, T Delaine, M Håkansson, S Genheden… - Journal of the …, 2010 - ACS Publications
… parameter and the sums run over all residues n of types m. C m = 1.32 for V and T, 3.1 for I
and L, and 2.31 for M. For tryptophan, C m was set to 3.02 on the basis of the value reported …

The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics

K Saraboji, M Håkansson, S Genheden, C Diehl… - Biochemistry, 2012 - ACS Publications
The recognition of carbohydrates by proteins is a fundamental aspect of communication
within and between living cells. Understanding the molecular basis of carbohydrate–protein …

The normal-mode entropy in the MM/GBSA method: effect of system truncation, buffer region, and dielectric constant

S Genheden, O Kuhn, P Mikulskis… - Journal of chemical …, 2012 - ACS Publications
We have performed a systematic study of the entropy term in the MM/GBSA (molecular
mechanics combined with generalized Born and surface-area solvation) approach to calculate …