Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but
the functional importance of this phenomenon remains unclear. Here, using genetic and …

Although hippocampal neurogenesis has been described in many adult mammals, the functional
impact of this process on physiology and behavior remains unclear. In the present study…

Environmental enrichment increases adult hippocampal neurogenesis and alters
hippocampal-dependent behavior in rodents. To investigate a causal link between these two …

… The water maze was a circular tank ∼1.2 m in diameter filled with water, which was made
opaque with nontoxic white paint. The water temperature was set at 25 ± 1C. For the standard …

BACKGROUND: Depression and anxiety disorders have been linked to dysfunction of the
hypothalamo-pituitary-adrenal (HPA) axis and structural changes within the hippocampus. …

Survival and integration of new neurons in the hippocampal circuit are rate-limiting steps in
adult hippocampal neurogenesis. Neuronal network activity is a major regulator of these …

… , followed by 4% cold paraformaldehyde/0.1 M phosphate buffer), and brains were collected
for … consisted of the following steps: 1 h incubation in 0.1 M TBS with 0.5% Triton X-100 (Tx) …

… between 2.7 μg/m 3 (40 ppbv) and 170 μg/m 3 (650 ppbv) (… a mass region of about m/z =
1000 (where m is the ion mass … 400 < m/z < 900 shows highly regular mass differences of m/…

… For doublecortin (DCX) staining, the procedure consisted of the following steps: 1-h incubation
in 0.1 M Tris-buffered saline (TBS) with 0.5% Triton X-100 and 10% normal donkey serum…

Autism spectrum disorder comprises several neurodevelopmental conditions presenting
symptoms in social communication and restricted, repetitive behaviors. A major roadblock for …