User profiles for M. Tafti

Mehdi Tafti

University of Lausanne
Verified email at unil.ch
Cited by 14911

Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment

…, T Sakurai, F Sallusto, TE Scammell, M Tafti… - Nature Reviews …, 2019 - nature.com
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy

RS Liblau, A Vassalli, A Seifinejad, M Tafti - The Lancet Neurology, 2015 - thelancet.com
The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most
important advance in sleep research and sleep medicine since the discovery of rapid eye …

Risks factors associated with offshore IT outsourcing

MHA Tafti - Industrial Management & Data Systems, 2005 - emerald.com
Purpose – To provide a framework for risk assessment of offshore IT outsourcing. Design/methodology/approach
– Based on review of recent literature, this paper has identified major …

Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study

…, G Waeber, P Vollenweider, M Tafti… - The Lancet …, 2015 - thelancet.com
Background Sleep-disordered breathing is associated with major morbidity and mortality.
However, its prevalence has mainly been selectively studied in populations at risk for sleep-…

The homeostatic regulation of sleep need is under genetic control

P Franken, D Chollet, M Tafti - Journal of Neuroscience, 2001 - Soc Neuroscience
Delta power, a measure of EEG activity in the 1–4 Hz range, in slow-wave sleep (SWS) is in
a quantitative and predictive relationship with prior wakefulness. Thus, sleep loss evokes a …

CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions

…, A Besset, J Touchon, M Billiard, M Tafti… - Journal of Neurology …, 2003 - jnnp.bmj.com
Objective: To determine the role of CSF hypocretin-1 in narcolepsy with and without
cataplexy, Kleine-Levin syndrome (KLS), idiopathic and other hypersomnias, and several …

[HTML][HTML] Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients

…, B Petit, H Hor, M Mühlethaler, M Tafti - The Journal of …, 2010 - Am Soc Clin Investig
… Bayer, as well as Michel Mühlethaler and Mehdi Tafti, contributed equally to this work. …
Laurence Bayer, as well as Michel Mühlethaler and Mehdi Tafti, contributed equally to this work. …

Sleep modulates haematopoiesis and protects against atherosclerosis

…, P Libby, M Tafti, TE Scammell, M Nahrendorf… - Nature, 2019 - nature.com
Sleep is integral to life 1 . Although insufficient or disrupted sleep increases the risk of
multiple pathological conditions, including cardiovascular disease 2 , we know little about the …

Homer1a is a core brain molecular correlate of sleep loss

…, BF O'Hara, P Franken, M Tafti - Proceedings of the …, 2007 - National Acad Sciences
… Paillusson, and M. Bueno for assistance in microarray and real-time RT-PCR analyses at …
Paillusson, and M. Bueno for assistance in microarray and real-time RT-PCR analyses at the …

T cells in patients with narcolepsy target self-antigens of hypocretin neurons

…, A Lanzavecchia, R Khatami, M Manconi, M Tafti… - Nature, 2018 - nature.com
… e, i, The frequencies of HCRT-specific cells (e) and TRIB2-specific cells (i) per million
memory CD4 + T (T m ) cells in patients with narcolepsy and controls are shown (e, NT1, n = 15; …