Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

…, LS Premkumar, H Takahashi, M Talantova… - Nature, 2002 - nature.com
… The polypeptide sequence contains 1,002 amino acids, corresponding to a calculated
relative molecular mass of 109,000 (M r 109K). Multiple sequence alignment of NR3B with other …

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

M Talantova, S Sanz-Blasco, X Zhang… - Proceedings of the …, 2013 - National Acad Sciences
Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer’s
disease (AD). However, the mechanism of synaptic damage remains incompletely …

Direct reprogramming of mouse fibroblasts to neural progenitors

J Kim, JA Efe, S Zhu, M Talantova… - Proceedings of the …, 2011 - National Acad Sciences
The simple yet powerful technique of induced pluripotency may eventually supply a wide
range of differentiated cells for cell therapy and drug development. However, making the …

[PDF][PDF] Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions

R Ambasudhan, M Talantova, R Coleman, X Yuan… - Cell stem cell, 2011 - cell.com
Human induced pluripotent stem cells (hiPSCs) have been generated by reprogramming a
number of different somatic cell types using a variety of approaches. In addition, direct …

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

S Okamoto, MA Pouladi, M Talantova, D Yao, P Xia… - Nature medicine, 2009 - nature.com
Huntington's disease is caused by an expanded CAG repeat in the gene encoding huntingtin
(HTT), resulting in loss of striatal and cortical neurons. Given that the gene product is …

[HTML][HTML] Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

…, J Parker, F Soldner, CR Sunico, S Nagar, M Talantova… - Cell, 2013 - cell.com
Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNpc). An association has been reported between PD and …

[PDF][PDF] Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels

E Bossy-Wetzel, MV Talantova, WD Lee, MN Schölzke… - Neuron, 2004 - cell.com
… (C) Neuronal cultures were loaded with Rhod-Zin3 AM (4 M) in imaging buffer and exposed
to SNOC (200 M). Rhod-Zin3 fluorescence was monitored over time at RT. TPEN (20 M) was …

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

…, R Ambasudhan, P Xia, M Talantova… - Proceedings of the …, 2011 - National Acad Sciences
Human embryonic stem cells (hESCs) hold enormous promise for regenerative medicine.
Typically, hESC-based applications would require their in vitro differentiation into a desirable …

[HTML][HTML] Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes

…, S Spiering, R Haverslag, C Kim, M Talantova… - PloS one, 2009 - journals.plos.org
Background Developmental, physiological and tissue engineering studies critical to the
development of successful myocardial regeneration therapies require new ways to effectively …

Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation

C Kim, M Majdi, P Xia, KA Wei, M Talantova… - Stem cells and …, 2010 - liebertpub.com
Various types of cardiomyocytes undergo changes in automaticity and electrical properties
during fetal heart development. Human embryonic stem cell-derived cardiomyocytes (hESC-…