[HTML][HTML] Placental serotonin: implications for the developmental effects of SSRIs and maternal depression

JC Velasquez, N Goeden, A Bonnin - Frontiers in cellular …, 2013 - frontiersin.org
In addition to its role in the pathophysiology of numerous psychiatric disorders, increasing
evidence points to serotonin (5-HT) as a crucial molecule for the modulation of …

A transient placental source of serotonin for the fetal forebrain

A Bonnin, N Goeden, K Chen, ML Wilson, J King… - Nature, 2011 - nature.com
… in half of the placentas (n = 4–6) for each pregnant mouse (n = 3); remaining placentas were
… frozen in liquid N 2 . Samples were then processed for HPLC analysis as described above. …

[HTML][HTML] Maternal and offspring pools of osteocalcin influence brain development and functions

…, CA Denny, A Gardin, A Chamouni, N Goeden… - Cell, 2013 - cell.com
The powerful regulation of bone mass exerted by the brain suggests the existence of bone-derived
signals modulating this regulation or other functions of the brain. We show here that …

[HTML][HTML] Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

MR Chuapoco, NC Flytzanis, N Goeden… - Nature …, 2023 - nature.com
… b,c, Unique barcode enrichments in viral DNA (left) and whole RNA (right) extracts from the
brain (b; n = 6 brain samples from two newborn macaques) and the liver (c; n = 2 liver tissue …

Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain

N Goeden, J Velasquez, KA Arnold… - Journal of …, 2016 - Soc Neuroscience
… In all experiments, dams were treated as individual experimental groups (1 dam, n = 1) and
fetuses (n = 3–5 of either sex per dam) as biological repeats. For every measure, the number …

[HTML][HTML] Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system

…, MR Chuapoco, X Chen, N Goeden… - Current Research in …, 2023 - Elsevier
Modern neuroscience approaches including optogenetics, calcium imaging, and other
genetic manipulations have facilitated our ability to dissect specific circuits in rodent models to …

[HTML][HTML] AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

D Goertsen, NC Flytzanis, N Goeden… - Nature …, 2022 - nature.com
… The only known receptors for AAV9 are N-linked terminal galactose 39 and the AAV receptor
40,41 , but the possibility of co-receptors is still unexplored. Binding interactions with cell …

[HTML][HTML] Impact of maternal serotonin transporter genotype on placental serotonin, fetal forebrain serotonin, and neurodevelopment

…, AMJ Anacker, TD Rogers, N Goeden… - …, 2017 - nature.com
Biomarker, neuroimaging, and genetic findings implicate the serotonin transporter (SERT) in
autism spectrum disorder (ASD). Previously, we found that adult male mice expressing the …

Prenatal dynamics of kynurenine pathway metabolism in mice: focus on kynurenic acid

N Goeden, FM Notarangelo, A Pocivavsek… - Developmental …, 2017 - karger.com
… On ED18, kynurenine (100 mg/kg), KYNA (10 mg/kg), or sterile saline was administered
orally to pregnant dams (n = 3/group). Based on the literature [26,32,33] and pilot data (not …

[HTML][HTML] Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

…, M Baikoghli, P Jain, X Ding, N Goeden… - Nature …, 2020 - nature.com
… The insertion site is located in the N-terminal disordered region of capsid proteins VP1 and
VP2. A similar modification was made in AAV9 and was shown to be accessible by labeling …