mTOR is a regulator of cell growth and survival, protein synthesis-dependent synaptic
plasticity, and autophagic degradation of cellular components. When triggered by mTOR …

… A similar induction of CHOP was also observed by Holtz and O'Malley in a gene expression
screen of neurotoxin models of parkinsonism (Holtz and O'Malley 2003). These investigators …

Objective: A prevailing concept in neuroscience has been that the adult mammalian central
nervous system is incapable of restorative axon regeneration. Recent evidence, however, …

Axon degeneration is a hallmark of neurodegenerative diseases, including Alzheimer's disease
and Parkinson's disease. Such degeneration is not a passive event but rather an active …

There are currently no therapies that provide either protection or restoration of neuronal
function for adult-onset neurodegenerative diseases such as Parkinson's disease (PD). Many …

10.7554/eLife.14810.001 The regulation of protein degradation is essential for maintaining
the appropriate environment to coordinate complex cell signaling events and to promote …

Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect and restore
dopamine (DA) neurons in injury models and is being evaluated for the treatment of Parkinson's …

Mutations in the gene for LRRK2 are the most common cause of familial Parkinson's disease
(PD) and patients with these mutations manifest clinical features that are indistinguishable …

Cyclin‐dependent kinase 5 is predominantly expressed in postmitotic neurons and plays a
role in neurite elongation during development. It has also been postulated to play a role in …

Brain-derived neurotrophic factor (BDNF) was the first purified molecule identified to directly
support the development of mesencephalic dopamine neurons. However, its physiologic …