User profiles for P. W. Mantyh

Patrick Mantyh

Professor, University of Arizona
Verified email at email.arizona.edu
Cited by 37179

[HTML][HTML] The cerebral signature for pain perception and its modulation

I Tracey, PW Mantyh - Neuron, 2007 - cell.com
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

The molecular dynamics of pain control

SP Hunt, PW Mantyh - Nature Reviews Neuroscience, 2001 - nature.com
Pain is necessary for survival, but persistent pain can result in anxiety, depression and a
reduction in the quality of life. The discriminative and affective qualities of pain are both thought …

Molecular mechanisms of cancer pain

PW Mantyh, DR Clohisy, M Koltzenburg… - Nature Reviews …, 2002 - nature.com
… The capacity of tumour cells to injure and destroy peripheral nerve fibres has been directly
observed in an experimental model of bone cancer (PW M, unpublished observations). After …

Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur

…, DR Clohisy, DJ Adams, P O'leary, PW Mantyh - Neuroscience, 2002 - Elsevier
Although skeletal pain plays a major role in reducing the quality of life in patients suffering
from osteoarthritis, Paget’s disease, sickle cell anemia and bone cancer, little is known about …

Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons

…, NM Luger, MC Sabino, DR Clohisy, PW Mantyh - Neuroscience, 2000 - Elsevier
The aim of this investigation was to determine whether murine models of inflammatory,
neuropathic and cancer pain are each characterized by a unique set of neurochemical changes …

Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor

PW Mantyh, SD Rogers, P Honore, BJ Allen… - Science, 1997 - science.org
Substance P is released in the spinal cord in response to painful stimuli, but its role in
nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-…

Primary afferent tachykinins are required to experience moderate to intense pain

YQ Cao, PW Mantyh, EJ Carlson, AM Gillespie… - Nature, 1998 - nature.com
The excitatory neurotransmitter glutamate coexists with the peptide known as substance P
in primary afferents that respond to painful stimulation 1 . Because blockers of glutamate …

Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain

…, ML Ramnaraine, DR Clohisy, PW Mantyh - Journal of …, 1999 - Soc Neuroscience
The cancer-related event that is most disruptive to the cancer patient's quality of life is pain.
To begin to define the mechanisms that give rise to cancer pain, we examined the …

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of β‐amyloid peptide

PW Mantyh, JR Ghilardi, S Rogers… - Journal of …, 1993 - Wiley Online Library
A major pathological feature of Alzheimer's disease (AD) is the presence of a high density of
amyloid plaques in the brain tissue of patients. The plaques are predominantly composed of …

Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord

…, ML Ramnaraine, DR Clohisy, PW Mantyh - Nature medicine, 2000 - nature.com
Bone cancer pain is common among cancer patients and can have a devastating effect on
their quality of life. A chief problem in designing new therapies for bone cancer pain is that it is …