User profiles for P. W. Mantyh
Patrick MantyhProfessor, University of Arizona Verified email at email.arizona.edu Cited by 37179 |
[HTML][HTML] The cerebral signature for pain perception and its modulation
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
The molecular dynamics of pain control
SP Hunt, PW Mantyh - Nature Reviews Neuroscience, 2001 - nature.com
Pain is necessary for survival, but persistent pain can result in anxiety, depression and a
reduction in the quality of life. The discriminative and affective qualities of pain are both thought …
reduction in the quality of life. The discriminative and affective qualities of pain are both thought …
Molecular mechanisms of cancer pain
PW Mantyh, DR Clohisy, M Koltzenburg… - Nature Reviews …, 2002 - nature.com
… The capacity of tumour cells to injure and destroy peripheral nerve fibres has been directly
observed in an experimental model of bone cancer (PW M, unpublished observations). After …
observed in an experimental model of bone cancer (PW M, unpublished observations). After …
Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur
Although skeletal pain plays a major role in reducing the quality of life in patients suffering
from osteoarthritis, Paget’s disease, sickle cell anemia and bone cancer, little is known about …
from osteoarthritis, Paget’s disease, sickle cell anemia and bone cancer, little is known about …
Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons
…, NM Luger, MC Sabino, DR Clohisy, PW Mantyh - Neuroscience, 2000 - Elsevier
The aim of this investigation was to determine whether murine models of inflammatory,
neuropathic and cancer pain are each characterized by a unique set of neurochemical changes …
neuropathic and cancer pain are each characterized by a unique set of neurochemical changes …
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
PW Mantyh, SD Rogers, P Honore, BJ Allen… - Science, 1997 - science.org
Substance P is released in the spinal cord in response to painful stimuli, but its role in
nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-…
nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-…
Primary afferent tachykinins are required to experience moderate to intense pain
The excitatory neurotransmitter glutamate coexists with the peptide known as substance P
in primary afferents that respond to painful stimulation 1 . Because blockers of glutamate …
in primary afferents that respond to painful stimulation 1 . Because blockers of glutamate …
Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain
…, ML Ramnaraine, DR Clohisy, PW Mantyh - Journal of …, 1999 - Soc Neuroscience
The cancer-related event that is most disruptive to the cancer patient's quality of life is pain.
To begin to define the mechanisms that give rise to cancer pain, we examined the …
To begin to define the mechanisms that give rise to cancer pain, we examined the …
Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of β‐amyloid peptide
PW Mantyh, JR Ghilardi, S Rogers… - Journal of …, 1993 - Wiley Online Library
A major pathological feature of Alzheimer's disease (AD) is the presence of a high density of
amyloid plaques in the brain tissue of patients. The plaques are predominantly composed of …
amyloid plaques in the brain tissue of patients. The plaques are predominantly composed of …
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord
…, ML Ramnaraine, DR Clohisy, PW Mantyh - Nature medicine, 2000 - nature.com
Bone cancer pain is common among cancer patients and can have a devastating effect on
their quality of life. A chief problem in designing new therapies for bone cancer pain is that it is …
their quality of life. A chief problem in designing new therapies for bone cancer pain is that it is …