Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro
owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a …

The molecular mechanisms underlying self-renewal of pluripotent embryonic stem (ES) cells
is still poorly understood. Deciphering these mechanisms is of prime importance for at least …

Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in
the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each …

Cell cycle regulation is critical for maintenance of genome integrity. A prominent factor that
guarantees genomic stability of cells is p53 (ref. 1). The P53 gene encodes a transcription …

Multipotential stem cells can be selected from the bone marrow by plastic adhesion, expanded,
and cultured. They are able to differentiate not only into multiple cell types, including …

We have investigated the cell cycle-related mechanisms that lead to the emergence of
primate areas 17 and 18. These areas are characterized by striking differences in …

… 40, Scientific Solutions Inc.) at 2 kHz (0.5 second steps) and 20 kHz (20 milliseconds steps),
filtered at 1/3 of the sampling rate and stored on the hard disc of a computer through the P-…

A short G1 phase is a characteristic feature of mouse embryonic stem cells (ESCs). To
determine if there is a causal relationship between G1 phase restriction and pluripotency, we …

The expression of the retinoblastoma susceptibility (RB-1) gene was investigated in highly
proliferating mouse embryonic stem (ES) cells and in slowly proliferating mouse embryonic …

The expression of E and D-type cyclins, Cyclin-Dependent Kinase (CDK) 2 and 4, as well
as CDK inhibitors p219" and p27" were examined during in vitro differentiation of mouse …