[HTML][HTML] Comparative lipidomic analysis of mouse and human brain with Alzheimer disease

RB Chan, TG Oliveira, EP Cortes, LS Honig… - Journal of Biological …, 2012 - ASBMB
Lipids are key regulators of brain function and have been increasingly implicated in
neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based approach …

[HTML][HTML] Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

E Morel, Z Chamoun, ZM Lasiecka, RB Chan… - Nature …, 2013 - nature.com
Defects in endosomal sorting have been implicated in Alzheimer’s disease. Endosomal traffic
is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized …

[PDF][PDF] Role for lipid droplet biogenesis and microlipophagy in adaptation to lipid imbalance in yeast

JD Vevea, EJ Garcia, RB Chan, B Zhou, M Schultz… - Developmental cell, 2015 - cell.com
The immediate responses to inhibition of phosphatidylcholine (PC) biosynthesis in yeast are
altered phospholipid levels, slow growth, and defects in the morphology and localization of …

The impact of chronic stress on the rat brain lipidome

TG Oliveira, RB Chan, FV Bravo, A Miranda… - Molecular …, 2016 - nature.com
Chronic stress is a major risk factor for several human disorders that affect modern societies.
The brain is a key target of chronic stress. In fact, there is growing evidence indicating that …

[HTML][HTML] Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

…, J Neufeld, S Shahriar, S Simoes, RB Chan… - Nature …, 2018 - nature.com
Defects in endolysosomal and autophagic functions are increasingly viewed as key
pathological features of neurodegenerative disorders. A master regulator of these functions is …

Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

…, KR Velasco, RR Agrawal, Y Xu, RB Chan… - The EMBO …, 2017 - embopress.org
In the amyloidogenic pathway associated with Alzheimer disease ( AD ), the amyloid precursor
protein ( APP ) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) …

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits

TG Oliveira, RB Chan, H Tian, M Laredo… - Journal of …, 2010 - Soc Neuroscience
Growing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While
phospholipases A2 and C have been recently shown to mediate key actions of amyloid β-…

[HTML][HTML] The phospholipase D1 pathway modulates macroautophagy

…, H Tian, E Morel, A Nezu, RB Chan… - Nature …, 2010 - nature.com
Although macroautophagy is known to be an essential degradative process whereby
autophagosomes mediate the engulfment and delivery of cytoplasmic components into lysosomes, …

[PDF][PDF] Synaptojanin 1-mediated PI (4, 5) P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission

B Chang-Ileto, SG Frere, RB Chan, SV Voronov… - Developmental cell, 2011 - cell.com
Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P 2 ] plays a fundamental role in clathrin-mediated
endocytosis. However, precisely how PI(4,5)P 2 metabolism is spatially and temporally …

[PDF][PDF] Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of Plasmodium falciparum

S Gulati, EH Ekland, KV Ruggles, RB Chan… - Cell host & …, 2015 - cell.com
During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo
synthesis and acquisition of host cell lipids. Consistent with this essential role, Plasmodium …