[HTML][HTML] Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
RB Chan, TG Oliveira, EP Cortes, LS Honig… - Journal of Biological …, 2012 - ASBMB
Lipids are key regulators of brain function and have been increasingly implicated in
neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based approach …
neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based approach …
[HTML][HTML] Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system
E Morel, Z Chamoun, ZM Lasiecka, RB Chan… - Nature …, 2013 - nature.com
Defects in endosomal sorting have been implicated in Alzheimer’s disease. Endosomal traffic
is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized …
is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized …
[PDF][PDF] Role for lipid droplet biogenesis and microlipophagy in adaptation to lipid imbalance in yeast
The immediate responses to inhibition of phosphatidylcholine (PC) biosynthesis in yeast are
altered phospholipid levels, slow growth, and defects in the morphology and localization of …
altered phospholipid levels, slow growth, and defects in the morphology and localization of …
The impact of chronic stress on the rat brain lipidome
Chronic stress is a major risk factor for several human disorders that affect modern societies.
The brain is a key target of chronic stress. In fact, there is growing evidence indicating that …
The brain is a key target of chronic stress. In fact, there is growing evidence indicating that …
[HTML][HTML] Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
…, J Neufeld, S Shahriar, S Simoes, RB Chan… - Nature …, 2018 - nature.com
Defects in endolysosomal and autophagic functions are increasingly viewed as key
pathological features of neurodegenerative disorders. A master regulator of these functions is …
pathological features of neurodegenerative disorders. A master regulator of these functions is …
Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
…, KR Velasco, RR Agrawal, Y Xu, RB Chan… - The EMBO …, 2017 - embopress.org
In the amyloidogenic pathway associated with Alzheimer disease ( AD ), the amyloid precursor
protein ( APP ) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) …
protein ( APP ) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) …
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits
TG Oliveira, RB Chan, H Tian, M Laredo… - Journal of …, 2010 - Soc Neuroscience
Growing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While
phospholipases A2 and C have been recently shown to mediate key actions of amyloid β-…
phospholipases A2 and C have been recently shown to mediate key actions of amyloid β-…
[HTML][HTML] The phospholipase D1 pathway modulates macroautophagy
…, H Tian, E Morel, A Nezu, RB Chan… - Nature …, 2010 - nature.com
Although macroautophagy is known to be an essential degradative process whereby
autophagosomes mediate the engulfment and delivery of cytoplasmic components into lysosomes, …
autophagosomes mediate the engulfment and delivery of cytoplasmic components into lysosomes, …
[PDF][PDF] Synaptojanin 1-mediated PI (4, 5) P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission
B Chang-Ileto, SG Frere, RB Chan, SV Voronov… - Developmental cell, 2011 - cell.com
Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P 2 ] plays a fundamental role in clathrin-mediated
endocytosis. However, precisely how PI(4,5)P 2 metabolism is spatially and temporally …
endocytosis. However, precisely how PI(4,5)P 2 metabolism is spatially and temporally …
[PDF][PDF] Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of Plasmodium falciparum
S Gulati, EH Ekland, KV Ruggles, RB Chan… - Cell host & …, 2015 - cell.com
During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo
synthesis and acquisition of host cell lipids. Consistent with this essential role, Plasmodium …
synthesis and acquisition of host cell lipids. Consistent with this essential role, Plasmodium …