Hearing depends on reliable and temporally precise neurotransmission by cochlear hair
cells. The wide dynamic range and high sensitivity with which these cells encode acoustic …

Sensorineural hearing loss, which stems primarily from the failure of mechanosensory hair
cells, changes the traveling waves that transmit acoustic signals along the cochlea. However, …

IIGP1 belongs to a well defined family of 47-kDa GTPases whose members are present at
low resting levels in mouse cells but are strongly induced transcriptionally by interferons and …

Background The interferon-inducible immunity-related GTPases (IRG proteins/p47 GTPases)
are a distinctive family of GTPases that function as powerful cell-autonomous resistance …

My thesis work focuses on the biochemical, structural and cellular characterisation of IIGP1,
a member of the p47 family of GTPases. The p47 family of GTPases are induced …

Interferon-inducible p47 GTPases are critical mediators of cell-autonomous resistance against
several intracellular pathogens. Here we present the first crystal structure of a member of …

The recently identified p47 GTPases are one of the most effective cell-autonomous resistance
systems known against intracellular pathogens in the mouse. One member of the family, …

… Praveen Kumar carried out bioinformatics analysis and performed the experiments with
assistance from Chinnappa Apattira Uthaiah. The synthesis of compounds was carried out by …

Hyperglycemia contributes to the development of cognition impairment and related disorders,
induces oxidative stress in neuronal cells; thereby, impairs normal signaling mechanisms …

Hyperglycemia contributes to the development of cognition impairment and related disorders,
induces oxidative stress in neuronal cells; thereby, impairs normal signaling mechanisms …