The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same precursor …

Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral
hypothalamus and send axons to numerous regions throughout the central nervous system…

Orexins (hypocretins) are neuropeptides synthesized in the central nervous system exclusively
by neurons of the lateral hypothalamus. Orexin‐containing neurons have widespread …

… of purposeful motor activity (Chemelli et al., 1999). The Sleepstatepatternsoforexin/ataxin-3micewerevery
similar to that of prepro-orexin knockout mice (Chemelli postural changes are …

… orexin knockout mice are also significantly hypophagic (Figure 4), but have normal body
weight suggesting differences in energy homeostasis and metabolic rate (RM Chemelli, …

The neuropeptide orexin (also known as hypocretin) is hypothesized to play a critical role in
the regulation of sleep–wake behavior. Lack of orexin produces narcolepsy, which is …

… no significant signal above backfrom wakefulness to REM sleep (Chemelli et al., 1999). …
by superfusion of orexin-A germline transmitting chimeric mice as described (Chemelli et al., …

Modafinil is an increasingly popular wake-promoting drug used for the treatment of narcolepsy,
but its precise mechanism of action is unknown. To determine potential pathways via …

Orexins (also called hypocretins) are peptide neurotransmitters expressed in neurons of the
lateral hypothalamic area (LHA). Mice lacking the orexin peptides develop narcolepsy-like …

Narcolepsy—cataplexy, a disorder of excessive sleepiness and abnormalities of rapid eye
movement (REM) sleep, results from deficiency of the hypothalamic orexin (hypocretin) …