Background The prevalence and magnitude of childhood obesity are increasing dramatically.
We examined the effect of varying degrees of obesity on the prevalence of the metabolic …

Background Childhood obesity, epidemic in the United States, has been accompanied by
an increase in the prevalence of type 2 diabetes among children and adolescents. We …

… requests that this document be cited as follows: Skyler JS, Bergenstal R, Bonow RO, Buse
J, Deedwania P, Gale EAM, Howard BV, Kirkman MS, Kosiborod M, Reaven P, Sherwin RS. …

Patients with insulin-dependent diabetes mellitus often have poor metabolic control during
puberty. To determine whether puberty is associated with decreased insulin-stimulated …

… To confirm that GHS-Rs are present in these areas, we analyzed GHS-R immunolabeling
in wild-type mice as well as β-galactosidase (β-gal) expression in the hippocampal formation …

OBJECTIVE—In a recent randomized controlled trial, lowering blood glucose levels to 80–110
mg/dl improved clinical outcomes in critically ill patients. In that study, the insulin infusion …

To improve plasma glucose control, we administered insulin via the subcutaneous route in
seven ambulatory patients with juvenile diabetes (12 to 17 years of age), using a portable …

… Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS: Defective glucose counterregulation
after … Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS: Intensive insulin therapy …

The design of the present study of the kinetics of insulin in man combines experimental
features which obviate two of the major problems in previous insulin studies. (a) The use of …

Ghrelin is a novel peptide that acts on the growth hormone (GH) secretagogue receptor in
the pituitary and hypothalamus. It may function as a third physiological regulator of GH …