[HTML][HTML] Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia

…, TA Jacobson, SB Ketchum, RT Doyle Jr… - … England Journal of …, 2019 - Mass Medical Soc
Background Patients with elevated triglyceride levels are at increased risk for ischemic
events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers triglyceride …

Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults

MD Spirito, G Morelli, RT Doyle, J Johnson… - Expert opinion on …, 2008 - Taylor & Francis
Background: Prescription omega-3-acid ethyl esters (P-OM3) have been used as adjunctive
therapy to statin drugs in patients with mixed hyperlipidemia. Objective: To assess the effect …

Effect of omega-3-acid ethyl esters on the steady-state plasma pharmacokinetics of rosuvastatin in healthy adults

P Gosai, J Liu, RT Doyle, J Johnson… - Expert opinion on …, 2008 - Taylor & Francis
RT Doyle and J Johnson are former employees of Reliant Pharmaceuticals and are now
clinical consultants to GlaxoSmithKline Corporation. R Carter is a former employee of Reliant …

Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind …

MH Davidson, EA Stein, HE Bays, KC Maki, RT Doyle… - Clinical …, 2007 - Elsevier
Background: Patients with elevated serum triglyceride (TG) levels often have elevations in
non-high-density lipoprotein cholesterol (non-HDL-C) levels as well. The National Cholesterol …

SNARE protein-dependent glutamate release from astrocytes

A Araque, N Li, RT Doyle, PG Haydon - Journal of Neuroscience, 2000 - Soc Neuroscience
We investigated the cellular mechanisms underlying the Ca 2+ -dependent release of
glutamate from cultured astrocytes isolated from rat hippocampus. Using Ca 2+ imaging and …

Effects of icosapent ethyl on total ischemic events: from REDUCE-IT

…, TA Jacobson, SB Ketchum, RT Doyle… - Journal of the American …, 2019 - jacc.org
Background : In time-to-first-event analyses, icosapent ethyl significantly reduced the risk of
ischemic events, including cardiovascular death, among patients with elevated triglycerides …

Rationale and design of REDUCE‐IT: reduction of cardiovascular events with icosapent ethyl–intervention trial

…, M Miller, JC Tardif, SB Ketchum, RT Doyle Jr… - Clinical …, 2017 - Wiley Online Library
Doyle Jr … Doyle Jr … Doyle, are current or former Amarin employees and shareholders.
Ms. Murphy has served as a consultant for Amarin and received honoraria from Merck. …

Baseline lipoprotein lipids and low-density lipoprotein cholesterol response to prescription omega-3 acid ethyl ester added to simvastatin therapy

KC Maki, MR Dicklin, MH Davidson, RT Doyle… - The American journal of …, 2010 - Elsevier
The present post hoc analysis of data from the COMBination of prescription Omega-3 with
Simvastatin (COMBOS) study investigated the predictors of the low-density lipoprotein (LDL) …

Long-term up to 24-month efficacy and safety of concomitant prescription omega-3-acid ethyl esters and simvastatin in hypertriglyceridemic patients

…, A Meadowcroft, R Schroyer, RT Doyle… - … medical research and …, 2010 - Taylor & Francis
Objective: Assess the long-term efficacy and safety of prescription omega-3-acid ethyl esters
(P-OM3) coadministered with simvastatin in an extension of the Combination of Prescription …

REDUCE-IT USA: results from the 3146 patients randomized in the United States

…, TA Jacobson, PG Steg, SB Ketchum, RT Doyle Jr… - Circulation, 2020 - Am Heart Assoc
Background: Some trials have found that patients from the United States derive less benefit
than patients enrolled outside the United States. This prespecified REDUCE-IT (Reduction of …