The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded
form of a naturally expressed protein. Despite the diversity of clinical symptoms associated …

Numerous epidemiological studies have shown a significantly higher risk for development
of Alzheimer’s disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular …

Prions are proteinaceous infectious agents responsible for the transmission of prion diseases.
The lack of a procedure for cultivating prions in the laboratory has been a major limitation …

Prions are the proteinaceous infectious agents responsible for the transmission of prion
diseases. The main or sole component of prions is the misfolded prion protein (PrP Sc ), which is …

Prions are composed of the misfolded prion protein (PrP Sc ) organized in a variety of aggregates.
An important question in the prion field has been to determine the identity of functional …

Amyloids are protein aggregates of highly regular structure that are involved in diverse
pathologies such as Alzheimer's and Parkinson's disease. Recent evidence has shown that …

Microcin E492 (Mcc) is a pore-forming bacteriotoxin. Mcc activity is inhibited at the stationary
phase by formation of amyloid-like aggregates in the culture. Here we report that, in a …

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Background Amyloids are highly ordered polypeptide aggregates stabilized by a beta-sheet
structural core. Though classically associated to pathology, reports on novel functional roles …

The cellular form of the prion protein (PrP c ) is necessary for the development of prion diseases
and is a highly conserved protein that may play a role in neuroprotection. PrP c is found …