User profiles for R. Morimoto

Richard I. Morimoto

Bill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, Northwestern
Verified email at northwestern.edu
Cited by 74293

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

RI Morimoto - Genes & development, 1998 - genesdev.cshlp.org
Our cells and tissues are challenged constantly by exposure to extreme conditions that cause
acute and chronic stress. Consequently, survival has necessitated the evolution of stress …

Adapting proteostasis for disease intervention

WE Balch, RI Morimoto, A Dillin, JW Kelly - science, 2008 - science.org
The protein components of eukaryotic cells face acute and chronic challenges to their
integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal …

Cells in stress: transcriptional activation of heat shock genes

RI Morimoto - Science, 1993 - science.org
The author is in the Department of Biochemistry, Mo-lecular and Cell Biology, Northwestern
University, 2153 Sheridan Road, Evanston, IL 60201. between hsp70 with the inactive form …

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

…, A Mahboubi, T Kuwana, P Tailor, RI Morimoto… - Nature cell …, 2000 - nature.com
… In control lysates (a), Apaf-1 was eluted as a complex of M r 200–300K (fractions … r 60–90K;
fractions 16–22). After dATP activation (b), Apaf-1 was found in the apoptosome complex (M r

[PDF][PDF] Geroscience: linking aging to chronic disease

…, ES Epel, C Franceschi, GJ Lithgow, RI Morimoto… - Cell, 2014 - cell.com
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

[HTML][HTML] Autophagy in healthy aging and disease

Y Aman, T Schmauck-Medina, M Hansen, RI Morimoto… - Nature aging, 2021 - nature.com
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Heat shock factors: integrators of cell stress, development and lifespan

M Åkerfelt, RI Morimoto, L Sistonen - Nature reviews Molecular cell …, 2010 - nature.com
Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress.
They are best known as inducible transcriptional regulators of genes encoding molecular …

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

C Jolly, RI Morimoto - Journal of the National Cancer Institute, 2000 - academic.oup.com
Morimoto RI. Regulation of the heat shock transcriptional response: cross talk between a
family of heat … Phillips B, Abravaya K, Morimoto RI. Analysis of the specificity and mechanism of …

Biological and chemical approaches to diseases of proteostasis deficiency

ET Powers, RI Morimoto, A Dillin… - Annual review of …, 2009 - annualreviews.org
… Thus, we suggest that modulation of the proteostasis network by PRs that reduce IGF1-R
signaling or upregulate HSF1 or FOXO are likely to be effective for aging-associated …

[HTML][HTML] Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

…, CY Liu, K Yang, A Solomon, H Yoshida, R Morimoto… - Cell, 2001 - cell.com
The unfolded protein response (UPR) is a transcriptional and translational intracellular
signaling pathway activated by the accumulation of unfolded proteins in the lumen of the …