… Jaenisch, R. Germ line integration and Mendelian transmission of the ex ogenous Moloney
… Jaenisch, R. Insertion of the bacterial gpt gene into the germ line of mice by retroviral …

Biochemistry and genetics are both required to elucidate the function of macromolecules.
There is no question that metallothioneins (MTs) have unique biochemical properties, but …

… Palmiter is professor of biochemistry at the Howard Hughes Medical Institute, Department
of Biochemistry, University of Washington, Seattle 98195, and Gunnar Norstedt is a visiting …

The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is still …

… 26), the H locus enhancer lies upstream of exon 1, while in the LTR-myc construct the
enhanc~r region of a murine retroviral L TR is positioned similarly16. In EK-SY- myc, the lymphoid-…

A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the
structural gene of rat growth hormone was microinjected into the pronuclei of fertilized mouse …

Direct microinjection has been used to introduce foreign DNA into a number of terminally
differentiated cell types as well as embryos of several species including sea urchin 1 , Candida …

Leptin is the primary signal through which the hypothalamus senses nutritional state and
modulates food intake and energy balance 1 . Leptin reduces food intake by upregulating …

Microinjection of foreign DNA into fertilized mammalian eggs is a convenient means of
introducing genes into the germ line. Some of the more important parameters that influence …

Experiments were designed to test the effect of introns on gene expression in transgenic
mice. Four different pairs of gene constructs, which were identical except that one member of …