User profiles for R. Tamayev
 | Dr. Robert TamayevVerified email at drtamayev.com Cited by 833 |
β‐but not γ‐secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
R Tamayev, S Matsuda, O Arancio… - EMBO molecular …, 2012 - embopress.org
A mutation in the BRI2/ITM2b gene causes loss of BRI2 protein leading to familial Danish
dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid‐β precursor protein (…
dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid‐β precursor protein (…
[HTML][HTML] The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains
R Tamayev, D Zhou, L D'Adamio - Molecular neurodegeneration, 2009 - Springer
Background Brain tissue from patients with Alzheimer's disease has shown an increase of
phosphorylation of Tyr-682, located on the conserved Y682ENPTY motif, and Thr-668 …
phosphorylation of Tyr-682, located on the conserved Y682ENPTY motif, and Thr-668 …
[HTML][HTML] Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
R Tamayev, L D'Adamio - Molecular neurodegeneration, 2012 - Springer
… Robert Tamayev and Luciano D’Adamio contributed equally to this work … Robert
Tamayev … Robert Tamayev and Luciano D’Adamio contributed equally to this work. …
Tamayev … Robert Tamayev and Luciano D’Adamio contributed equally to this work. …
[HTML][HTML] Tyr682 in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo
APM Barbagallo, R Weldon, R Tamayev, D Zhou… - PloS one, 2010 - journals.plos.org
Background The pathogenesis of Alzheimer's disease is attributed to misfolding of Amyloid-β
(Aβ) peptides. Aβ is generated during amyloidogenic processing of Aβ-precursor protein (…
(Aβ) peptides. Aβ is generated during amyloidogenic processing of Aβ-precursor protein (…
Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
R Tamayev, S Matsuda, M Fà… - Proceedings of the …, 2010 - National Acad Sciences
According to the prevailing “amyloid cascade hypothesis,” genetic dementias such as
Alzheimer’s disease and familial Danish dementia (FDD) are caused by amyloid deposits that …
Alzheimer’s disease and familial Danish dementia (FDD) are caused by amyloid deposits that …
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis
R Tamayev, L Giliberto, W Li, C d'Abramo… - Journal of …, 2010 - Soc Neuroscience
… Differently from the FDD KI , we produced a 332 bp fragment containing the ABri mutation
(t798a substitution, leading to a Stop→R transition at codon 267 and to the introduction of an …
(t798a substitution, leading to a Stop→R transition at codon 267 and to the introduction of an …
APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
R Tamayev, S Matsuda, L Giliberto, O Arancio… - The EMBO …, 2011 - embopress.org
… APP–Bri2 complexes are detected in T and R extracts but not S extracts. (B) P2 fraction was
prepared from FDD KI (F) and wild‐type (W) mouse brains. P2 was extracted with the Hepes‐…
prepared from FDD KI (F) and wild‐type (W) mouse brains. P2 was extracted with the Hepes‐…
T yr682 in the A β‐precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance
C Matrone, S Luvisetto, LR La Rosa, R Tamayev… - Aging cell, 2012 - Wiley Online Library
Processing of A β‐precursor protein ( APP ) plays an important role in A lzheimer's disease (
AD ) pathogenesis. The APP intracellular domain contains residues important in regulating …
AD ) pathogenesis. The APP intracellular domain contains residues important in regulating …
Increased AβPP processing in familial Danish dementia patients
S Matsuda, R Tamayev… - Journal of Alzheimer's …, 2011 - content.iospress.com
An autosomal dominant mutation in the BRI2/ITM2B gene causes Familial Danish Dementia
(FDD). We have generated a mouse model of FDD, called FDD KI, genetically congruous to …
(FDD). We have generated a mouse model of FDD, called FDD KI, genetically congruous to …
Memory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency
R Tamayev, L D'Adamio - Journal of Neuroscience, 2012 - Soc Neuroscience
… Analysis of these mice has shown that the British mutation causes memory impairments
due to loss of Bri2 function ( Tamayev et al., 2010b ). BRI2 is a physiologic inhibitor of …
due to loss of Bri2 function ( Tamayev et al., 2010b ). BRI2 is a physiologic inhibitor of …