Recent studies highlight the importance of the RB1 tumor suppressor as a target for cancer
therapy. Canonically, RB1 regulates cell cycle progression and represents the downstream …

The mammalian brain contains neural stem cells (NSCs) that allow continued neurogenesis
throughout the life of the animal. However, neurogenesis is known to decline during aging …

Mcm2 is a component of the DNA replication licensing complex that marks DNA replication
origins during G1 of the cell cycle for use in the subsequent S-phase. It is expressed in stem/…

Replication origins, fragile sites, and rDNA have been implicated as sources of chromosomal
instability. However, the defining genomic features of replication origins and fragile sites …

Using complete genome analysis, we sequenced five bladder tumors accrued from patients
with muscle-invasive transitional cell carcinoma of the urinary bladder (TCC-UB) and …

Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100–200 repeats of a 9.1kb
sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus. Copy …

… Dr Pruitt's work has been funded by the NIH. He is the founder and owner of the Buffalo
Molecular Target Laboratories. Dr Kunnev, Dr Rusiniak, Ms Kudla, Ms Freeland and Ms Cady …

Genomic instability within somatic stem cells may lead to the accumulation of mutations and
contribute to cancer or other age‐related phenotypes. However, determining the frequency …

Insufficient cell proliferation has been suggested as a potential cause of age-related tissue
dysgenesis in mammals. However, genetic manipulation of cell cycle regulators in the germ …

A reporter construct was assembled with 4-kb of renin 5′-flanking sequence fused to
humanized green fluorescent protein (GFP) cDNA. Transgenic mice carrying this construct were …