… Crandall et al. reveal the dynamic mechanisms of cortical control over thalamic gating, …
T-type calcium channels by the strong preceding IPSPs (Crandall et al., 2010; Errington et al., …

Efficient derivation of large-scale motor neurons (MNs) from human pluripotent stem cells is
central to the understanding of MN development, modelling of MN disorders in vitro and …

The visual selection of specific cells within an ex vivo brain slice, combined with whole-cell
patch clamp recording and capillary electrophoresis (CE)–mass spectrometry (MS)-based …

The low-threshold transient calcium current (I T ) plays a critical role in modulating the firing
behavior of thalamic neurons; however, the role of I T in the integration of afferent information …

The rodent somatosensory cortex includes well-defined examples of cortical columns—the
barrel columns—that extend throughout the cortical depth and are defined by discrete …

Tuberous sclerosis is a developmental genetic disorder caused by mutations in TSC1,
which results in epilepsy, autism, and intellectual disability. The cause of these neurological …

Layer 6 corticothalamic (L6 CT) neurons are in a strategic position to control sensory input
to the neocortex, yet we understand very little about their functions. Apart from studying their …

Dopamine (DA) receptors are the principal targets of drugs used in the treatment of schizophrenia.
Among the five DA receptor subtypes, the D 4 subtype is of particular interest because …

Short-term plasticity regulates the strength of central synapses as a function of previous
activity. In the neocortex, direct synaptic interactions between areas play a central role in …

Sleep abnormalities are coexpressed with human communication disorders. Recent data
from the birdsong system, the best model for human speech, indicate that sleep has a critical …