User profiles for S. Costantino

Sarah Costantino

- Verified email at uzh.ch - Cited by 14440

Santiago Costantino

- Verified email at umontreal.ca - Cited by 3960

Ageing, metabolism and cardiovascular disease

S Costantino, F Paneni… - The Journal of physiology, 2016 - Wiley Online Library
Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential increase …

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

KM Fairbrass, SJ Costantino, DJ Gracie… - The lancet …, 2020 - thelancet.com
Background Patients with inflammatory bowel disease (IBD) often report symptoms compatible
with irritable bowel syndrome (IBS), which might have an effect on psychological health. …

Insulin resistance, diabetes, and cardiovascular risk

F Paneni, S Costantino, F Cosentino - Current atherosclerosis reports, 2014 - Springer
Obesity and type 2 diabetes mellitus (T2DM) are major drivers of cardiovascular disease (CVD).
The link between environmental factors, obesity, and dysglycemia indicates that …

[HTML][HTML] Spatiotemporal image correlation spectroscopy (STICS) theory, verification, and application to protein velocity mapping in living CHO cells

B Hebert, S Costantino, PW Wiseman - Biophysical journal, 2005 - cell.com
We introduce a new extension of image correlation spectroscopy (ICS) and image cross-correlation
spectroscopy (ICCS) that relies on complete analysis of both the temporal and …

The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures

…, N Durisic, JM Mativetsky, S Costantino… - Molecular biology of …, 2007 - Am Soc Cell Biol
… 7.4, 150 mM NaCl, 3.4 mM EDTA, and 0.005% P-20) and injected at 10 μl/min (120-s
association + 120-s dissociation) over the reference SA and active oligonucleotide surfaces (∼200 …

Spatially mapping the immune landscape of melanoma using imaging mass cytometry

…, HS Najafabadi, S Gravel, S Costantino… - Science …, 2022 - science.org
Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …

Gene Silencing of the Mitochondrial Adaptor p66Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

…, P Mocharla, A Akhmedov, S Costantino… - Circulation …, 2012 - Am Heart Assoc
Rationale: Hyperglycemic memory may explain why intensive glucose control has failed to
improve cardiovascular outcomes in patients with diabetes. Indeed, hyperglycemia promotes …

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A

…, J Mancini, M Klagsbrun, S Costantino… - Blood, The Journal …, 2011 - ashpublications.org
… Scotopic ERGs were obtained in response to progressively brighter flashes of white light
ranging in intensity from −6.3 log to 0.9 log cd/s/m 2 in 0.3-log-unit increments (using a …

Stalled developmental programs at the root of pediatric brain tumors

…, H Sartelet, PE Lutz, C Nagy, G Turecki, S Costantino… - Nature …, 2019 - nature.com
Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental
states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal …

Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c …

S Costantino, F Paneni, R Battista, L Castello… - Diabetes, 2017 - Am Diabetes Assoc
… , Billerica, MA) according to the manufacturer’s instructions. ChIP was performed with 10 μg
anti-… S.Co. and FP contributed to the study conception, data analysis and interpretation, and …