DCX, a new mediator of the JNK pathway

A Gdalyahu, I Ghosh, T Levy, T Sapir, S Sapoznik… - The EMBO …, 2004 - embopress.org
… DCX C-terminus contains multiple S/TP residues that fit consensus JNK phosphorylation …
that DCX is phosphorylated with some phosphorylation site(s) residing on a peptide 317–338 (…

Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma

K Bahar-Shany, H Brand, S Sapoznik… - Gynecologic …, 2014 - Elsevier
Objectives Ovulation-related inflammation is suspected to have a causal role in ovarian
carcinogenesis, but there are no human models to study the molecular pathways. Our aim is to …

Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration

T Sapir, S Sapoznik, T Levy, D Finkelshtein… - Journal of …, 2008 - Soc Neuroscience
… L–S , Improvement of neuronal migration inhibition induced by MARK2 shRNA by addition
of … S , Control shRNA with GFP demonstrates that the rescue is partial. Scale bar sizes are …

Novel immunotherapy for malignant melanoma with a monoclonal antibody that blocks CEACAM1 homophilic interactions

…, L Raz, L Hershkovitz, A Ben Arav, S Sapoznik… - Molecular cancer …, 2012 - AACR
CEACAM1 (biliary glycoprotein-1, CD66a) was reported as a strong clinical predictor of
poor prognosis in melanoma. We have previously identified CEACAM1 as a tumor escape …

[HTML][HTML] Microvesicle proteomic profiling of uterine liquid biopsy for ovarian cancer early detection

GD Barnabas, K Bahar-Shany, S Sapoznik… - Molecular & cellular …, 2019 - ASBMB
High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological
malignancies, because of diagnosis at a metastatic stage. Current screening options fail to …

Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more

O Reiner, S Sapoznik, T Sapir - Neuromolecular medicine, 2006 - Springer
Lissencephaly 1 (LIS1) was the first gene implicated in the pathogenesis of type-1 lissencephaly.
More than a decade of research by multiple laboratories has revealed that LIS1 is a …

CEACAM1 in malignant melanoma: a diagnostic and therapeutic target

S Sapoznik, R Ortenberg, J Schachter… - Current Topics in …, 2012 - ingentaconnect.com
CEACAM1 adhesion molecule is broadly expressed, participates in pivotal cellular and
immunological processes and is involved in cancer. Originally identified as a tumor suppressor, it …

[HTML][HTML] Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms

S Sapoznik, O Hammer, R Ortenberg… - Journal of Immunology …, 2012 - hindawi.com
… The current dogma on tumor progression under immune pressure is of the three “E”s:
elimination, equilibrium, and escape [1]. In the first phase, the innate and adaptive immune system …

CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy

S Sapoznik, R Ortenberg, G Galore-Haskel… - Cancer Immunology …, 2012 - Springer
… , 95 % ethanol, and 100 % ethanol for 10 s each. Before coverslipping, sections were cleared
in xylene for 10 s and mounted with Entellan. Stained sections were reviewed by an expert …

Systemic dysregulation of CEACAM1 in melanoma patients

G Markel, R Ortenberg, R Seidman, S Sapoznik… - Cancer Immunology …, 2010 - Springer
… prognostic factor using Breslow’s score [4–6]. However, using Breslow’s score allows initial
… They share a common basic structure of sequentially ordered different Ig-like domain(s) with …