User profiles for S. Schiaffino

Stefano Schiaffino

Veneto Institute of Molecular Medicine (VIMM), Padova
Verified email at unipd.it
Cited by 53610

Mechanisms regulating skeletal muscle growth and atrophy

S Schiaffino, KA Dyar, S Ciciliot, B Blaauw… - The FEBS …, 2013 - Wiley Online Library
… Similar changes are found in other fast rat muscles (S. Schiaffino and S. Ciciliot, unpublished
data); however, the type 1 fibers of the slow soleus show marked atrophy after denervation, …

Fiber types in mammalian skeletal muscles

S Schiaffino, C Reggiani - Physiological reviews, 2011 - journals.physiology.org
… to the slow-twitch motor units (S) (117). It should be stressed that the resistance to fatigue
of FR motor unit is lower compared with that of S motor units. A further contribution to the …

Molecular diversity of myofibrillar proteins: gene regulation and functional significance

S Schiaffino, C Reggiani - Physiological reviews, 1996 - journals.physiology.org
Myofibrillar proteins exist as multiple isoforms that derive from multigene (isogene) families.
Additional isoforms, including products of tropomyosin, myosin light chain 1 fast, troponin T, …

[HTML][HTML] Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

…, C Skurk, E Calabria, A Picard, K Walsh, S Schiaffino… - Cell, 2004 - cell.com
… Thus, forkhead factor(s) play a critical role in the development of muscle atrophy, and …
mechanisms and influence the same transcription factor(s). Low levels of insulin and probably IGF-…

[HTML][HTML] Burning plasma achieved in inertial fusion

…, MS Rubery, JD Salmonson, J Sater, S Schiaffino… - Nature, 2022 - nature.com
Obtaining a burning plasma is a critical step towards self-sustaining fusion energy 1. A burning
plasma is one in which the fusion reactions themselves are the primary source of heating …

[HTML][HTML] FoxO3 controls autophagy in skeletal muscle in vivo

…, R Di Lisi, C Sandri, J Zhao, AL Goldberg, S Schiaffino… - Cell metabolism, 2007 - cell.com
Autophagy allows cell survival during starvation through the bulk degradation of proteins and
organelles by lysosomal enzymes. However, the mechanisms responsible for the induction …

[HTML][HTML] FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

…, JJ Brault, A Schild, P Cao, M Sandri, S Schiaffino… - Cell metabolism, 2007 - cell.com
Muscle atrophy occurs in many pathological states and results primarily from accelerated
protein degradation and activation of the ubiquitin-proteasome pathway. However, the …

Three myosin heavy chain isoforms in type 2 skeletal muscle fibres

S Schiaffino, L Gorza, S Sartore, L Saggin… - Journal of Muscle …, 1989 - Springer
… & SCHIAFFINO, S. (1981) Fast isomyosins and fiber types in mammalian skeletal muscle.
J. … SARTORE, S., GORZA, L. & SCHIAFFINO, S. (1982) Ferai myosin heavy chain in …

[PDF][PDF] Autophagy is required to maintain muscle mass

…, M Komatsu, D Metzger, C Reggiani, S Schiaffino… - Cell metabolism, 2009 - cell.com
… (Pierce) according to the manufacturer’s instructions and reprobed if necessary. Detergent-soluble
… We gratefully acknowledged S. Burden for the gift of MLC1f-Cre mice and the FP6 …

Force‐velocity relations and myosin heavy chain isoform compositions of skinned fibres from rat skeletal muscle.

R Bottinelli, S Schiaffino… - The Journal of physiology, 1991 - Wiley Online Library
1. This study was performed to assess whether muscle contractile properties are related to
the presence of specific myosin heavy chain (MHC) isoforms. 2. Force‐velocity relations and …